Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia

H J Bontkes, T D de Gruijl, A Bijl, R H M Verheijen, C J L M Meijer, R J Scheper, P L Stern, J E Burns, N J Maitland, J M M Walboomers

Research output: Contribution to journalArticlepeer-review

Abstract

T-cell-mediated immune responses against mucosal oncogenic types of human papillomaviruses (HPV) are thought to play a role in the control of the virus infection and its associated cervical lesions. The in vitro production of interleukin-2 by T-helper (Th) cells in response to the C-terminal and N-terminal domains of the HPV-16 E2 protein was determined in 74 women with cytological evidence of premalignant cervical epithelial neoplasia who participated in a non-intervention follow-up (FU) study, Cross-sectional analysis at the end of FU showed that Th cell responses against the C-terminal domain were associated with evidence of previous or present HPV-16 infection as compared to patients with no evidence of any HPV infection (18.9% versus 0%, P = 0.039). Th cell responses against the N-terminal domain were not associated with evidence of HPV-16 infection. No association with disease outcome was observed with Th cell responses against either of the E2 protein domains. However, longitudinal analysis revealed that Th cell responses against the C-terminal domain frequently occur at the time of virus clearance. Whether these responses are responsible for the clearance of the virus is not known.

Original languageEnglish
Pages (from-to)2453-2459
Number of pages7
JournalJournal of general virology
Volume80
Publication statusPublished - Sep 1999

Keywords

  • E2 PROTEIN
  • NATURAL-HISTORY
  • IN-VITRO
  • ANTIBODIES
  • CANCER
  • TRANSCRIPTION
  • VIRUS
  • ACTIVATION
  • EXPRESSION
  • REPRESSOR

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