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From the same journal

Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia

Research output: Contribution to journalArticle

Author(s)

  • H J Bontkes
  • T D de Gruijl
  • A Bijl
  • R H M Verheijen
  • C J L M Meijer
  • R J Scheper
  • P L Stern
  • J E Burns
  • N J Maitland
  • J M M Walboomers

Department/unit(s)

Publication details

JournalJournal of general virology
DatePublished - Sep 1999
Volume80
Number of pages7
Pages (from-to)2453-2459
Original languageEnglish

Abstract

T-cell-mediated immune responses against mucosal oncogenic types of human papillomaviruses (HPV) are thought to play a role in the control of the virus infection and its associated cervical lesions. The in vitro production of interleukin-2 by T-helper (Th) cells in response to the C-terminal and N-terminal domains of the HPV-16 E2 protein was determined in 74 women with cytological evidence of premalignant cervical epithelial neoplasia who participated in a non-intervention follow-up (FU) study, Cross-sectional analysis at the end of FU showed that Th cell responses against the C-terminal domain were associated with evidence of previous or present HPV-16 infection as compared to patients with no evidence of any HPV infection (18.9% versus 0%, P = 0.039). Th cell responses against the N-terminal domain were not associated with evidence of HPV-16 infection. No association with disease outcome was observed with Th cell responses against either of the E2 protein domains. However, longitudinal analysis revealed that Th cell responses against the C-terminal domain frequently occur at the time of virus clearance. Whether these responses are responsible for the clearance of the virus is not known.

    Research areas

  • E2 PROTEIN, NATURAL-HISTORY, IN-VITRO, ANTIBODIES, CANCER, TRANSCRIPTION, VIRUS, ACTIVATION, EXPRESSION, REPRESSOR

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