By the same authors

From the same journal

Human papillomavirus type 16 infection of the cervix: a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein

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Standard

Human papillomavirus type 16 infection of the cervix : a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein. / Lacey, C J; Wells, M; Macdermott, R I; Gibson, P E.

In: Genitourinary medicine, Vol. 67, No. 2, 1991, p. 87-91.

Research output: Contribution to journalArticle

Harvard

Lacey, CJ, Wells, M, Macdermott, RI & Gibson, PE 1991, 'Human papillomavirus type 16 infection of the cervix: a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein', Genitourinary medicine, vol. 67, no. 2, pp. 87-91.

APA

Lacey, C. J., Wells, M., Macdermott, R. I., & Gibson, P. E. (1991). Human papillomavirus type 16 infection of the cervix: a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein. Genitourinary medicine, 67(2), 87-91.

Vancouver

Lacey CJ, Wells M, Macdermott RI, Gibson PE. Human papillomavirus type 16 infection of the cervix: a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein. Genitourinary medicine. 1991;67(2):87-91.

Author

Lacey, C J ; Wells, M ; Macdermott, R I ; Gibson, P E. / Human papillomavirus type 16 infection of the cervix : a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein. In: Genitourinary medicine. 1991 ; Vol. 67, No. 2. pp. 87-91.

Bibtex - Download

@article{f34908545797419b9d2fd06689b18dd5,
title = "Human papillomavirus type 16 infection of the cervix: a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein",
abstract = "An immuno-peroxidase technique using monoclonal antibodies against the major capsid protein L1 of HPV-16 was compared with dot-blot hybridisation of cervical scrapes and in situ hybridisation of cervical biopsy specimens for HPV-16 DNA. In a series of 20 patients all techniques were specific for HPV-16 infection. Ten patients were positive by dot-blot hybridisation and half of those were positive by in situ hybridisation. Only one of HPV-16 DNA positive cases showed L1 protein expression, apparently shortly after the onset of clinical infection. Whether major capsid protein expression reflects episodes of viral replication deserves further study.",
keywords = "Adult, Antibodies, Monoclonal, Blotting, Southern, Capsid, Capsid Proteins, Cervix Uteri, DNA Probes, HPV, Female, Humans, Immunohistochemistry, Oncogene Proteins, Viral, Papillomaviridae, Tumor Virus Infections, Uterine Cervical Diseases",
author = "Lacey, {C J} and M Wells and Macdermott, {R I} and Gibson, {P E}",
year = "1991",
language = "English",
volume = "67",
pages = "87--91",
journal = "Genitourinary medicine",
issn = "0266-4348",
publisher = "BMJ Publishing Group",
number = "2",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Human papillomavirus type 16 infection of the cervix

T2 - a comparison of differing DNA detection modes and the use of monoclonal antibodies against the major capsid protein

AU - Lacey, C J

AU - Wells, M

AU - Macdermott, R I

AU - Gibson, P E

PY - 1991

Y1 - 1991

N2 - An immuno-peroxidase technique using monoclonal antibodies against the major capsid protein L1 of HPV-16 was compared with dot-blot hybridisation of cervical scrapes and in situ hybridisation of cervical biopsy specimens for HPV-16 DNA. In a series of 20 patients all techniques were specific for HPV-16 infection. Ten patients were positive by dot-blot hybridisation and half of those were positive by in situ hybridisation. Only one of HPV-16 DNA positive cases showed L1 protein expression, apparently shortly after the onset of clinical infection. Whether major capsid protein expression reflects episodes of viral replication deserves further study.

AB - An immuno-peroxidase technique using monoclonal antibodies against the major capsid protein L1 of HPV-16 was compared with dot-blot hybridisation of cervical scrapes and in situ hybridisation of cervical biopsy specimens for HPV-16 DNA. In a series of 20 patients all techniques were specific for HPV-16 infection. Ten patients were positive by dot-blot hybridisation and half of those were positive by in situ hybridisation. Only one of HPV-16 DNA positive cases showed L1 protein expression, apparently shortly after the onset of clinical infection. Whether major capsid protein expression reflects episodes of viral replication deserves further study.

KW - Adult

KW - Antibodies, Monoclonal

KW - Blotting, Southern

KW - Capsid

KW - Capsid Proteins

KW - Cervix Uteri

KW - DNA Probes, HPV

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Oncogene Proteins, Viral

KW - Papillomaviridae

KW - Tumor Virus Infections

KW - Uterine Cervical Diseases

M3 - Article

VL - 67

SP - 87

EP - 91

JO - Genitourinary medicine

JF - Genitourinary medicine

SN - 0266-4348

IS - 2

ER -