Hybrid Self-Assembled Gel Beads for Tunable pH-Controlled Rosuvastatin Delivery

Anna Patterson; Carmen Cristina Piras; David Kelham Smith

doi:10.1002/chem.202101405

Hybrid Self-Assembled Gel Beads for Tunable pH-Controlled Rosuvastatin Delivery

Anna Patterson, Carmen Cristina Piras, David Kelham Smith

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

This article describes the fabrication of new pH-responsive hybrid gel beads based on combining the polymer gelator calcium alginate with two different low molecular weight gelators (LMWGs) based on 1,3:2,4-dibenzylidene-D-sorbitol: pH-responsive DBS-COOH and thermally-responsive DBS-CONHNH2, clearly demonstrating that different classes of LMWG can be fabricated into gel beads using this approach. We also demonstrate that self-assembled multi-component gel beads can be formed using different combinations of these gelators. The different gel bead formulations exhibit different responsiveness – the DBS-COOH network can disassemble within those beads in which it is present on raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin. The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 – primary control of this process results from the pKa of the API. The extent of pH-mediated API release, is also significantly further modified according to gel bead composition. The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, while the three-component DBS-COOH/DBS-CONHNH2/alginate system shows controlled slow release of the API under the same conditions. These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug delivery applications.

Original language	English
Pages (from-to)	13203-13210
Journal	Chemistry : A European Journal
Volume	27
Early online date	4 Aug 2021
DOIs	https://doi.org/10.1002/chem.202101405
Publication status	Published - 4 Aug 2021

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chem.202101405
© 2021 The Authors.
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Cite this

@article{b6552802a95b48f4b12aec88aec4154f,

title = "Hybrid Self-Assembled Gel Beads for Tunable pH-Controlled Rosuvastatin Delivery",

abstract = "This article describes the fabrication of new pH-responsive hybrid gel beads based on combining the polymer gelator calcium alginate with two different low molecular weight gelators (LMWGs) based on 1,3:2,4-dibenzylidene-D-sorbitol: pH-responsive DBS-COOH and thermally-responsive DBS-CONHNH2, clearly demonstrating that different classes of LMWG can be fabricated into gel beads using this approach. We also demonstrate that self-assembled multi-component gel beads can be formed using different combinations of these gelators. The different gel bead formulations exhibit different responsiveness – the DBS-COOH network can disassemble within those beads in which it is present on raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads, we explored aspects of the delivery of the lipid-lowering active pharmaceutical ingredient (API) rosuvastatin. The release profile of this statin from the hybrid gel beads is pH-dependent, with greater release at pH 7.4 than at pH 4.0 – primary control of this process results from the pKa of the API. The extent of pH-mediated API release, is also significantly further modified according to gel bead composition. The DBS-COOH/alginate beads show rapid, highly effective drug release at pH 7.4, while the three-component DBS-COOH/DBS-CONHNH2/alginate system shows controlled slow release of the API under the same conditions. These initial results indicate that such gel beads constitute a promising, versatile and easily tuned platform suitable for further development for controlled drug delivery applications.",

author = "Anna Patterson and Piras, {Carmen Cristina} and Smith, {David Kelham}",

note = "{\textcopyright} 2021 The Authors.",

year = "2021",

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doi = "10.1002/chem.202101405",

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AU - Patterson, Anna

AU - Piras, Carmen Cristina

AU - Smith, David Kelham

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