Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones

Chris Spicer*, William George Grey, Lydia Barber, Ksenia Stankevich, Vlado Lazarov, Adam Kerrigan, Angela Ramirez Rosales

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Thiol-reactive Michael acceptors are commonly used for the formation of chemically cross-linked hydrogels. In this paper, we address the drawbacks of many Michael acceptors by introducing pyridazinediones as new cross-linking agents. Through the use of pyridazinediones and their mono- or dibrominated analogues, we show that the mechanical strength, swelling ratio, and rate of gelation can all be controlled in a pH-sensitive manner. Moreover, we demonstrate that the degradation of pyridazinedione-gels can be induced by the addition of thiols, thus providing a route to responsive or dynamic gels, and that monobromo-pyridazinedione gels are able to support the proliferation of human cells. We anticipate that our results will provide a valuable and complementary addition to the existing toolkit of cross-linking agents, allowing researchers to tune and rationally design the properties of biomedical hydrogels.
Original languageEnglish
Early online date4 Oct 2023
Publication statusPublished - 4 Oct 2023

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