Hyperpolarizing Pyruvate through Signal Amplification By Reversible Exchange (SABRE)

TY - JOUR

T1 - Hyperpolarizing Pyruvate through Signal Amplification By Reversible Exchange (SABRE)

AU - Iali, Wissam

AU - Roy, Soumya S

AU - Tickner, Ben J

AU - Ahwal, Fadi

AU - Kennerley, Aneurin J

AU - Duckett, Simon

N1 - © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2019/6/17

Y1 - 2019/6/17

N2 - Hyperpolarization methods that premagnetise agents such as pyruvate are currently receiving significant attention. This is because they produce sensitivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonance. Here, we communicate how Signal Amplification by Reversible Exchange (SABRE) can provide strong ¹³C pyruvate signal enhancements in seconds through the formation of the novel polarization transfer catalyst [Ir(H)₂(η²-pyruvate)(DMSO)(IMes)]. By harnessing SABRE, strong signals for 1-¹³C and 2-¹³C pyruvate in addition to a long-lived singlet state in the 1,2-¹³C₂ form are readily created, the latter can be observed five minutes after the initial hyperpolarization step. We also demonstrate how this development may help with future studies of chemical reactivity.

AB - Hyperpolarization methods that premagnetise agents such as pyruvate are currently receiving significant attention. This is because they produce sensitivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonance. Here, we communicate how Signal Amplification by Reversible Exchange (SABRE) can provide strong ¹³C pyruvate signal enhancements in seconds through the formation of the novel polarization transfer catalyst [Ir(H)₂(η²-pyruvate)(DMSO)(IMes)]. By harnessing SABRE, strong signals for 1-¹³C and 2-¹³C pyruvate in addition to a long-lived singlet state in the 1,2-¹³C₂ form are readily created, the latter can be observed five minutes after the initial hyperpolarization step. We also demonstrate how this development may help with future studies of chemical reactivity.

KW - SABRE

KW - catalysis

KW - hyperpolarization

KW - pyruvate

KW - singlet state

UR - http://www.scopus.com/inward/record.url?scp=85067648655&partnerID=8YFLogxK

U2 - 10.1002/anie.201905483

DO - 10.1002/anie.201905483

M3 - Article

C2 - 31115970

SN - 1433-7851

VL - 58

SP - 10271

EP - 10275

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 30

ER -