Projects per year
Abstract
Hyperpolarization methods that premagnetise agents such as pyruvate are currently receiving significant attention. This is because they produce sensitivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonance. Here, we communicate how Signal Amplification by Reversible Exchange (SABRE) can provide strong ¹³C pyruvate signal enhancements in seconds through the formation of the novel polarization transfer catalyst [Ir(H)₂(η²-pyruvate)(DMSO)(IMes)]. By harnessing SABRE, strong signals for 1-¹³C and 2-¹³C pyruvate in addition to a long-lived singlet state in the 1,2-¹³C₂ form are readily created, the latter can be observed five minutes after the initial hyperpolarization step. We also demonstrate how this development may help with future studies of chemical reactivity.
Original language | English |
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Pages (from-to) | 10271-10275 |
Number of pages | 5 |
Journal | Angewandte Chemie International Edition |
Volume | 58 |
Issue number | 30 |
Early online date | 22 May 2019 |
DOIs | |
Publication status | Published - 17 Jun 2019 |
Bibliographical note
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.Keywords
- SABRE
- catalysis
- hyperpolarization
- pyruvate
- singlet state
Profiles
Projects
- 3 Finished
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EPSRC IAA: Securing IP for new route to hyperpolarise pyruvate
Duckett, S. B. (Principal investigator)
1/12/18 → 31/12/19
Project: Other project (funded) › Restricted grant
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National Centre for Translational Hyperpolarised Magnetic Resonance
Summerfield, Q. (Principal investigator), Duckett, S. B. (Co-investigator) & Green, G. G. R. (Co-investigator)
MEDICAL RESEARCH COUNCIL (MRC)
1/01/15 → 31/12/21
Project: Research project (funded) › Research
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Hyperpolarisation using SABRE as a new tool for imaging
Duckett, S. B. (Principal investigator) & Green, G. G. R. (Co-investigator)
1/10/12 → 31/03/19
Project: Research project (funded) › Research
Datasets
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Hyperpolarizing Pyruvate via Signal Amplification By Reversible Exchange (SABRE)
Duckett, S. B. (Creator), Iali, W. (Creator), Roy, S. S. (Creator), Tickner, B. J. (Creator), Ahwal, F. (Creator) & Kennerley, A. J. (Creator), University of York, 29 May 2019
DOI: 10.15124/8e796d66-b890-47e1-a8ab-598dab29eb16
Dataset