Hypersensitive response to over-reactive cysteines

Sascha Hoogendoorn, Lianne Willems, Bogdan I. Florea, Herman S. Overkleeft

Research output: Contribution to journalArticlepeer-review


Finding the active cysteine in a hay stack: In the search for active proteins and active-site peptides in a proteome, techniques such as quantitative proteomics and protein profiling with activity-based probes (ABPs; see picture) are commonly used. A recently developed proteomics technique combines these approaches to globally identify reactive cysteines, and possibly other amino acids, in a complex proteome.

Original languageEnglish
Pages (from-to)5434-5436
Number of pages3
JournalAngewandte Chemie International Edition
Issue number24
Publication statusPublished - 6 Jun 2011


  • activity-based profiling
  • cysteine
  • proteins
  • proteomics

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