Hypersensitive response to over-reactive cysteines

TY - JOUR

T1 - Hypersensitive response to over-reactive cysteines

AU - Hoogendoorn, Sascha

AU - Willems, Lianne

AU - Florea, Bogdan I.

AU - Overkleeft, Herman S.

PY - 2011/6/6

Y1 - 2011/6/6

N2 - Finding the active cysteine in a hay stack: In the search for active proteins and active-site peptides in a proteome, techniques such as quantitative proteomics and protein profiling with activity-based probes (ABPs; see picture) are commonly used. A recently developed proteomics technique combines these approaches to globally identify reactive cysteines, and possibly other amino acids, in a complex proteome.

AB - Finding the active cysteine in a hay stack: In the search for active proteins and active-site peptides in a proteome, techniques such as quantitative proteomics and protein profiling with activity-based probes (ABPs; see picture) are commonly used. A recently developed proteomics technique combines these approaches to globally identify reactive cysteines, and possibly other amino acids, in a complex proteome.

KW - activity-based profiling

KW - cysteine

KW - proteins

KW - proteomics

UR - http://www.scopus.com/inward/record.url?scp=79958036389&partnerID=8YFLogxK

U2 - 10.1002/anie.201100938

DO - 10.1002/anie.201100938

M3 - Article

C2 - 21574225

AN - SCOPUS:79958036389

VL - 50

SP - 5434

EP - 5436

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 24

ER -