By the same authors

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Identification of the first gene transfer agent (GTA) small terminase in Rhodobacter capsulatus and its role in GTA production and packaging of DNA: Identification of the first GTA TerS

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Publication details

DateAccepted/In press - 10 Sep 2019
DateE-pub ahead of print - 18 Sep 2019
DatePublished (current) - 13 Nov 2019
Issue number23
Number of pages17
Pages (from-to)1-17
Early online date18/09/19
Original languageEnglish


Genetic exchange mediated by viruses of bacteria (bacteriophages) is the primary driver of rapid bacterial evolution. The priority of viruses is usually to propagate themselves. Most bacteriophages use the small terminase protein to identify their own genome and direct its inclusion into phage capsids. Gene transfer agents (GTAs) are descended from bacteriophages but they instead package fragments of the entire bacterial genome without preference for their own genes. GTAs don’t selectively target specific DNA and no GTA small terminases are known. Here, we identified the small terminase from the model Rhodobacter capsulatus GTA, which then allowed prediction of analogues in other species. We examined the role of the small terminase in GTA production and propose a structural basis for random DNA packaging.

Bibliographical note

© 2019 Sherlock et al.

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