IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen

Matthias Eberl, E Beck, P S Coulson, H Okamura, R A Wilson, A P Mountford

Research output: Contribution to journalArticlepeer-review


Due to the synergistic effects of IL-12 and IL-18, and to their importance in establishing a Th1 type immune response, we investigated the potential of a combined administration of both cytokines as an adjuvant for recombinant antigens. As a model system, we used a schistosome T cell antigen recently identified in our group. By co-adsorption of this antigen on alum in the presence of IL-12 and IL-18, we demonstrate that IL-18 enhances the effects of IL-12 in inducing an antigen-specific Th1 type CD4(+) T cell response as well as high titres of IgG1, IgG2a, and IgG2b antibodies.
Original languageEnglish
Pages (from-to)2002-8
Number of pages7
Issue number19
Publication statusPublished - 2000


  • Adjuvants, Immunologic
  • Animals
  • Antibodies, Helminth
  • Antigens
  • Antigens, Helminth
  • Drug Synergism
  • Female
  • Helminth Proteins
  • Immunoglobulin G
  • Interleukin-12
  • Interleukin-18
  • Mice
  • Mice, Inbred C57BL
  • Recombinant Proteins
  • Schistosoma mansoni
  • Th1 Cells

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