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Illustration of a simple route to generate strong carbon-13 NMR signals that are detectable for several minutes

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JournalChemistry : A European Journal
DateAccepted/In press - 18 Jun 2017
DateE-pub ahead of print (current) - 19 Jun 2017
Number of pages6
Pages (from-to)1-6
Early online date19/06/17
Original languageEnglish

Abstract

Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. While hyperpolarization techniques increase sensitivity there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here we demonstrate a route to create hyperpolarized magnetization in ¹³C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization we achieve more than three-orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of ca 190 s in low-field which leads to a ¹³C-signal that is visible for 10 minutes.

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© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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