Imaged deconvolution: A method for extracting high-resolution NMR spectra from inhomogeneous fields

Meghan E. Halse, Paul T. Callaghan

Research output: Contribution to journalArticlepeer-review


We present a novel method for obtaining high resolution NMR spectra in the presence of grossly inhomogeneous magnetic fields, such as those encountered in one-sided access NMR. Our method combines the well-known principle of reference deconvolution with NMR imaging in order to resolve spectral features with frequency resolution orders of magnitude smaller than the prevailing line-broadening due to field inhomogeneity. We demonstrate that, in cases of inhomogeneous field line-broadening more than an order of magnitude larger than the spectral features to be resolved, rather than performing reference deconvolution on the sample as a whole, it is more favourable in terms of SNR to divide the target region of a sample into smaller sub-regions, by means of chemical shift imaging, and then to perform reference deconvolution on the individual sub-region spectra, finally summing the results In this way, significant resolution enhancements can be obtained in the presence of severe magnetic field inhomogeneity without an unacceptable loss in SNR.
Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalJournal of Magnetic Resonance
Issue number1
Early online date28 Dec 2006
Publication statusPublished - Mar 2007


  • NMR
  • Spectroscopy
  • High-resolution
  • Deconvolution
  • Imaging
  • Inhomogenous fields

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