Abstract
We present a novel method for obtaining high resolution NMR spectra in the presence of grossly inhomogeneous magnetic fields, such as those encountered in one-sided access NMR. Our method combines the well-known principle of reference deconvolution with NMR imaging in order to resolve spectral features with frequency resolution orders of magnitude smaller than the prevailing line-broadening due to field inhomogeneity. We demonstrate that, in cases of inhomogeneous field line-broadening more than an order of magnitude larger than the spectral features to be resolved, rather than performing reference deconvolution on the sample as a whole, it is more favourable in terms of SNR to divide the target region of a sample into smaller sub-regions, by means of chemical shift imaging, and then to perform reference deconvolution on the individual sub-region spectra, finally summing the results In this way, significant resolution enhancements can be obtained in the presence of severe magnetic field inhomogeneity without an unacceptable loss in SNR.
| Original language | English |
|---|---|
| Pages (from-to) | 130-137 |
| Number of pages | 8 |
| Journal | Journal of Magnetic Resonance |
| Volume | 185 |
| Issue number | 1 |
| Early online date | 28 Dec 2006 |
| DOIs | |
| Publication status | Published - Mar 2007 |
Keywords
- NMR
- Spectroscopy
- High-resolution
- Deconvolution
- Imaging
- Inhomogenous fields