Imaging of the host/parasite interplay in cutaneous leishmaniasis

Owain R Millington, Elmarie Myburgh, Jeremy C Mottram, James Alexander

Research output: Contribution to journalReview articlepeer-review


An understanding of host-parasite interplay is essential for the development of therapeutics and vaccines. Immunoparasitologists have learned a great deal from 'conventional'in vitro and in vivo approaches, but recent developments in imaging technologies have provided us (immunologists and parasitologists) with the ability to ask new and exciting questions about the dynamic nature of the parasite-immune system interface. These studies are providing us with new insights into the mechanisms involved in the initiation of a Leishmania infection and the consequent induction and regulation of the immune response. Here, we review some of the recent developments and discuss how these observations can be further developed to understand the immunology of cutaneous Leishmania infection in vivo.

Original languageEnglish
Pages (from-to)310-7
Number of pages8
JournalExperimental parasitology
Issue number3
Publication statusPublished - Nov 2010

Bibliographical note

(c) 2010 Elsevier Inc. All rights reserved.


  • Animals
  • Host-Parasite Interactions/immunology
  • Humans
  • Immune System/cytology
  • Leishmania/immunology
  • Leishmaniasis, Cutaneous/immunology
  • Luminescence
  • Microscopy, Fluorescence
  • Phagosomes/parasitology
  • Protozoan Vaccines

Cite this