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Imine reductases (IREDs)

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Author(s)

  • Juan Mangas-Sanchez
  • Scott P France
  • Sarah L Montgomery
  • Godwin A Aleku
  • Henry Man
  • Mahima Sharma
  • Jeremy I Ramsden
  • Gideon Grogan
  • Nicholas J Turner

Department/unit(s)

Publication details

JournalCurrent Opinion in Chemical Biology
DateAccepted/In press - 25 Nov 2016
DateE-pub ahead of print - 27 Dec 2016
DatePublished (current) - Apr 2017
Volume37
Number of pages7
Pages (from-to)19-25
Early online date27/12/16
Original languageEnglish

Abstract

Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.

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© 2016 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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