Immortalisation of normal human urothelial cells compromises differentiation capacity

Nikolaos T Georgopoulos; Lisa A Kirkwood; Claire L Varley; Nicola J Maclaine; Naveed Aziz; Jennifer Southgate

doi:10.1016/j.eururo.2011.02.022

Immortalisation of normal human urothelial cells compromises differentiation capacity

Nikolaos T Georgopoulos, Lisa A Kirkwood, Claire L Varley, Nicola J Maclaine, Naveed Aziz, Jennifer Southgate

Research output: Contribution to journal › Article › peer-review

Abstract

The development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade. Although tumour grade is an independent prognostic marker for urothelial carcinoma (UC), the molecular events underpinning the loss of urothelial differentiation are poorly understood.

Original language	English
Pages (from-to)	141-149
Number of pages	9
Journal	European Urology
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/j.eururo.2011.02.022
Publication status	Published - Jul 2011

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10.1016/j.eururo.2011.02.022

http://www.sciencedirect.com/science/article/pii/S0302283811001540

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title = "Immortalisation of normal human urothelial cells compromises differentiation capacity",

abstract = "The development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade. Although tumour grade is an independent prognostic marker for urothelial carcinoma (UC), the molecular events underpinning the loss of urothelial differentiation are poorly understood.",

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AU - Aziz, Naveed

AU - Southgate, Jennifer

PY - 2011/7

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AB - The development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade. Although tumour grade is an independent prognostic marker for urothelial carcinoma (UC), the molecular events underpinning the loss of urothelial differentiation are poorly understood.

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VL - 60

SP - 141

EP - 149

JO - European Urology

JF - European Urology

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Immortalisation of normal human urothelial cells compromises differentiation capacity

Abstract

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