Immortalisation of normal human urothelial cells compromises differentiation capacity

Nikolaos T Georgopoulos, Lisa A Kirkwood, Claire L Varley, Nicola J Maclaine, Naveed Aziz, Jennifer Southgate

Research output: Contribution to journalArticlepeer-review


The development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade. Although tumour grade is an independent prognostic marker for urothelial carcinoma (UC), the molecular events underpinning the loss of urothelial differentiation are poorly understood.
Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalEuropean Urology
Issue number1
Publication statusPublished - Jul 2011

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