Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour

R. Alan Wilson; Patricia S. Coulson

doi:10.1016/j.pt.2009.05.011

Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour

R. Alan Wilson, Patricia S. Coulson

Biology

Research output: Contribution to journal › Literature review › peer-review

Abstract

A recombinant antigen vaccine against Schistosoma mansoni remains elusive, in part because the parasite deploys complex defensive and offensive strategies to combat immune attack. Nevertheless, research on rodent and primate models has shown that schistosomes can be defeated when appropriate responses are elicited. Acquired protection appears to involve protracted inhibition of larval migration or key molecular processes at the adult surfaces, not rapid cytolytic killing mechanisms. A successful vaccine will likely require a cocktail of antigens rather than a single recombinant protein. In addition, ways need to be found of keeping the immune system on permanent alert, either to achieve adequate inhibition of protein function in adults, or because a trickle of incoming parasites does not amplify the secondary response.

Original language	English
Pages (from-to)	423-431
Number of pages	9
Journal	Trends in parasitology
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.pt.2009.05.011
Publication status	Published - Sep 2009

Keywords

RADIATION-ATTENUATED VACCINE
HAMSTER-CHEEK POUCH
PROTEOMIC ANALYSIS
ADULT WORMS
IN-VIVO
CERCARIAL SECRETIONS
PROTECTIVE IMMUNITY
SURFACE-MEMBRANES
GENE-EXPRESSION
ANIMAL-MODELS

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title = "Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour",

abstract = "A recombinant antigen vaccine against Schistosoma mansoni remains elusive, in part because the parasite deploys complex defensive and offensive strategies to combat immune attack. Nevertheless, research on rodent and primate models has shown that schistosomes can be defeated when appropriate responses are elicited. Acquired protection appears to involve protracted inhibition of larval migration or key molecular processes at the adult surfaces, not rapid cytolytic killing mechanisms. A successful vaccine will likely require a cocktail of antigens rather than a single recombinant protein. In addition, ways need to be found of keeping the immune system on permanent alert, either to achieve adequate inhibition of protein function in adults, or because a trickle of incoming parasites does not amplify the secondary response.",

keywords = "RADIATION-ATTENUATED VACCINE, HAMSTER-CHEEK POUCH, PROTEOMIC ANALYSIS, ADULT WORMS, IN-VIVO, CERCARIAL SECRETIONS, PROTECTIVE IMMUNITY, SURFACE-MEMBRANES, GENE-EXPRESSION, ANIMAL-MODELS",

author = "Wilson, {R. Alan} and Coulson, {Patricia S.}",

year = "2009",

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doi = "10.1016/j.pt.2009.05.011",

language = "English",

volume = "25",

pages = "423--431",

journal = "Trends in parasitology",

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T1 - Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour

AU - Wilson, R. Alan

AU - Coulson, Patricia S.

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N2 - A recombinant antigen vaccine against Schistosoma mansoni remains elusive, in part because the parasite deploys complex defensive and offensive strategies to combat immune attack. Nevertheless, research on rodent and primate models has shown that schistosomes can be defeated when appropriate responses are elicited. Acquired protection appears to involve protracted inhibition of larval migration or key molecular processes at the adult surfaces, not rapid cytolytic killing mechanisms. A successful vaccine will likely require a cocktail of antigens rather than a single recombinant protein. In addition, ways need to be found of keeping the immune system on permanent alert, either to achieve adequate inhibition of protein function in adults, or because a trickle of incoming parasites does not amplify the secondary response.

AB - A recombinant antigen vaccine against Schistosoma mansoni remains elusive, in part because the parasite deploys complex defensive and offensive strategies to combat immune attack. Nevertheless, research on rodent and primate models has shown that schistosomes can be defeated when appropriate responses are elicited. Acquired protection appears to involve protracted inhibition of larval migration or key molecular processes at the adult surfaces, not rapid cytolytic killing mechanisms. A successful vaccine will likely require a cocktail of antigens rather than a single recombinant protein. In addition, ways need to be found of keeping the immune system on permanent alert, either to achieve adequate inhibition of protein function in adults, or because a trickle of incoming parasites does not amplify the secondary response.

KW - RADIATION-ATTENUATED VACCINE

KW - HAMSTER-CHEEK POUCH

KW - PROTEOMIC ANALYSIS

KW - ADULT WORMS

KW - IN-VIVO

KW - CERCARIAL SECRETIONS

KW - PROTECTIVE IMMUNITY

KW - SURFACE-MEMBRANES

KW - GENE-EXPRESSION

KW - ANIMAL-MODELS

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U2 - 10.1016/j.pt.2009.05.011

DO - 10.1016/j.pt.2009.05.011

M3 - Literature review

VL - 25

SP - 423

EP - 431

JO - Trends in parasitology

JF - Trends in parasitology

SN - 1471-4922

IS - 9

ER -

Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour

Abstract

Keywords

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