Immunophenotype of transitional metaplasia of the uterine cervix

Patricia Harnden; Wendy Kennedy; Alison C. Andrew; Jennifer Southgate

Immunophenotype of transitional metaplasia of the uterine cervix

Patricia Harnden^*, Wendy Kennedy, Alison C. Andrew, Jennifer Southgate

^*Corresponding author for this work

Jack Birch Unit

Research output: Contribution to journal › Article › peer-review

Abstract

Transitional, glandular, and squamous epithelia show distinctive patterns of expression of cytokeratins 13, 17, 18, and 20. Furthermore, some markers, such as cytokeratin (CK) 20 and the asymmetric unit membrane, are related to terminal urothelial differentiation, their expression limited to superficial and occasional intermediate cells. In this study, seven cases fulfilling the morphologic criteria of transitional metaplasia of the uterine cervix were investigated with these markers to determine whether there was evidence of true urothelial-type differentiation in these lesions. Results were consistent and showed clear differences between the squamous, glandular, and metaplastic transitional areas of the cervix. In particular, the expression of CK13, CK17, and CK18 in the metaplastic areas was identical to the pattern observed in normal urothelium. However, full urothelial differentiation was not observed, as CK20 and asymmetric unit membrane were never expressed in the transitional metaplasia. Based on these findings, the term of immature transitional metaplasia would be a more accurate description of this entity.

Original language	English
Pages (from-to)	125-129
Number of pages	5
Journal	International Journal of Gynecological Pathology
Volume	18
Issue number	2
Publication status	Published - 1 Apr 1999

Keywords

Asymmetric unit membrane
Cytokeratin
Metaplasia
Uterine cervix

Cite this

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title = "Immunophenotype of transitional metaplasia of the uterine cervix",

abstract = "Transitional, glandular, and squamous epithelia show distinctive patterns of expression of cytokeratins 13, 17, 18, and 20. Furthermore, some markers, such as cytokeratin (CK) 20 and the asymmetric unit membrane, are related to terminal urothelial differentiation, their expression limited to superficial and occasional intermediate cells. In this study, seven cases fulfilling the morphologic criteria of transitional metaplasia of the uterine cervix were investigated with these markers to determine whether there was evidence of true urothelial-type differentiation in these lesions. Results were consistent and showed clear differences between the squamous, glandular, and metaplastic transitional areas of the cervix. In particular, the expression of CK13, CK17, and CK18 in the metaplastic areas was identical to the pattern observed in normal urothelium. However, full urothelial differentiation was not observed, as CK20 and asymmetric unit membrane were never expressed in the transitional metaplasia. Based on these findings, the term of immature transitional metaplasia would be a more accurate description of this entity.",

keywords = "Asymmetric unit membrane, Cytokeratin, Metaplasia, Uterine cervix",

author = "Patricia Harnden and Wendy Kennedy and Andrew, {Alison C.} and Jennifer Southgate",

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TY - JOUR

T1 - Immunophenotype of transitional metaplasia of the uterine cervix

AU - Harnden, Patricia

AU - Kennedy, Wendy

AU - Andrew, Alison C.

AU - Southgate, Jennifer

PY - 1999/4/1

Y1 - 1999/4/1

N2 - Transitional, glandular, and squamous epithelia show distinctive patterns of expression of cytokeratins 13, 17, 18, and 20. Furthermore, some markers, such as cytokeratin (CK) 20 and the asymmetric unit membrane, are related to terminal urothelial differentiation, their expression limited to superficial and occasional intermediate cells. In this study, seven cases fulfilling the morphologic criteria of transitional metaplasia of the uterine cervix were investigated with these markers to determine whether there was evidence of true urothelial-type differentiation in these lesions. Results were consistent and showed clear differences between the squamous, glandular, and metaplastic transitional areas of the cervix. In particular, the expression of CK13, CK17, and CK18 in the metaplastic areas was identical to the pattern observed in normal urothelium. However, full urothelial differentiation was not observed, as CK20 and asymmetric unit membrane were never expressed in the transitional metaplasia. Based on these findings, the term of immature transitional metaplasia would be a more accurate description of this entity.

AB - Transitional, glandular, and squamous epithelia show distinctive patterns of expression of cytokeratins 13, 17, 18, and 20. Furthermore, some markers, such as cytokeratin (CK) 20 and the asymmetric unit membrane, are related to terminal urothelial differentiation, their expression limited to superficial and occasional intermediate cells. In this study, seven cases fulfilling the morphologic criteria of transitional metaplasia of the uterine cervix were investigated with these markers to determine whether there was evidence of true urothelial-type differentiation in these lesions. Results were consistent and showed clear differences between the squamous, glandular, and metaplastic transitional areas of the cervix. In particular, the expression of CK13, CK17, and CK18 in the metaplastic areas was identical to the pattern observed in normal urothelium. However, full urothelial differentiation was not observed, as CK20 and asymmetric unit membrane were never expressed in the transitional metaplasia. Based on these findings, the term of immature transitional metaplasia would be a more accurate description of this entity.

KW - Asymmetric unit membrane

KW - Cytokeratin

KW - Metaplasia

KW - Uterine cervix

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VL - 18

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JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

IS - 2

ER -

Immunophenotype of transitional metaplasia of the uterine cervix

Abstract

Keywords

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