Impaired word recognition in Alzheimer's disease: The role of age of acquisition

TY - JOUR

T1 - Impaired word recognition in Alzheimer's disease

T2 - The role of age of acquisition

AU - Cuetos, Fernando

AU - Herrera, Elena

AU - Ellis, Andrew W.

PY - 2010/9

Y1 - 2010/9

N2 - Studies of word production in patients with Alzheimer's disease have identified the age of acquisition of words as an important predictor of retention or loss, with early acquired words remaining accessible for longer than later acquired words. If, as proposed by current theories, effects of age of acquisition reflect the involvement of semantic representations in task performance, then some aspects of word recognition in patients with Alzheimer's disease should also be better for early than later acquired words. We employed a version of the lexical decision task which we term the lexical selection task. This required participants to indicate which of four items on a page was a real word (the three 'foils' being orthographically plausible nonwords). Twenty-two patients with probable Alzheimer's disease were compared with an equal number of matched controls. The controls made few errors on the test, demonstrating that the controls were cognitively intact, and that the words were familiar to participants of their age and level of education. The Alzheimer patients were impaired overall, and recognized fewer late than early acquired words correctly. Performance of the Alzheimer patients on the lexical selection task correlated significantly with their scores on the mini mental state examination. Word recognition becomes impaired as Alzheimer's disease progresses, at which point effects of age of acquisition can be observed on the accuracy of performance. (C) 2010 Elsevier Ltd. All rights reserved.

AB - Studies of word production in patients with Alzheimer's disease have identified the age of acquisition of words as an important predictor of retention or loss, with early acquired words remaining accessible for longer than later acquired words. If, as proposed by current theories, effects of age of acquisition reflect the involvement of semantic representations in task performance, then some aspects of word recognition in patients with Alzheimer's disease should also be better for early than later acquired words. We employed a version of the lexical decision task which we term the lexical selection task. This required participants to indicate which of four items on a page was a real word (the three 'foils' being orthographically plausible nonwords). Twenty-two patients with probable Alzheimer's disease were compared with an equal number of matched controls. The controls made few errors on the test, demonstrating that the controls were cognitively intact, and that the words were familiar to participants of their age and level of education. The Alzheimer patients were impaired overall, and recognized fewer late than early acquired words correctly. Performance of the Alzheimer patients on the lexical selection task correlated significantly with their scores on the mini mental state examination. Word recognition becomes impaired as Alzheimer's disease progresses, at which point effects of age of acquisition can be observed on the accuracy of performance. (C) 2010 Elsevier Ltd. All rights reserved.

KW - Alzheimer's disease

KW - Dementia

KW - Age of acquisition

KW - Lexical decision

KW - Word recognition

KW - CUMULATIVE-FREQUENCY HYPOTHESIS

KW - SEMANTIC MEMORY LOSS

KW - LEXICAL-DECISION

KW - OBJECT RECOGNITION

KW - DEMENTIA

KW - VARIABLES

KW - BRAIN

KW - INTELLIGENCE

KW - MECHANISMS

KW - SEVERITY

UR - http://www.scopus.com/inward/record.url?scp=77955846137&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2010.07.017

DO - 10.1016/j.neuropsychologia.2010.07.017

M3 - Article

VL - 48

SP - 3329

EP - 3334

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 11

ER -