Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.

Kirsten Dundas, Melanie J Shears, Photini Sinnis, Gavin J Wright

Research output: Contribution to journalArticlepeer-review


Malaria is an infectious disease, caused by Plasmodium parasites, that remains a major global health problem. Infection begins when salivary gland sporozoites are transmitted through the bite of an infected mosquito. Once within the host, sporozoites navigate through the dermis, into the bloodstream, and eventually invade hepatocytes. While we have an increasingly sophisticated cellular description of this journey, our molecular understanding of the extracellular interactions between the sporozoite and mammalian host that regulate migration and invasion remain comparatively poor. Here, we review the current state of our understanding, highlight the technical limitations that have frustrated progress, and outline how new approaches will help to address this knowledge gap with the ultimate aim of improving malaria treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalTrends in parasitology
Issue number2
Early online date21 Dec 2018
Publication statusPublished - 1 Feb 2019

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