Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.

Kirsten Dundas; Melanie J Shears; Photini Sinnis; Gavin J Wright

doi:10.1016/j.pt.2018.11.008

Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.

Kirsten Dundas, Melanie J Shears, Photini Sinnis, Gavin J Wright

Research output: Contribution to journal › Article › peer-review

Abstract

Malaria is an infectious disease, caused by Plasmodium parasites, that remains a major global health problem. Infection begins when salivary gland sporozoites are transmitted through the bite of an infected mosquito. Once within the host, sporozoites navigate through the dermis, into the bloodstream, and eventually invade hepatocytes. While we have an increasingly sophisticated cellular description of this journey, our molecular understanding of the extracellular interactions between the sporozoite and mammalian host that regulate migration and invasion remain comparatively poor. Here, we review the current state of our understanding, highlight the technical limitations that have frustrated progress, and outline how new approaches will help to address this knowledge gap with the ultimate aim of improving malaria treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	129-139
Number of pages	11
Journal	Trends in parasitology
Volume	35
Issue number	2
Early online date	21 Dec 2018
DOIs	https://doi.org/10.1016/j.pt.2018.11.008
Publication status	Published - 1 Feb 2019

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10.1016/j.pt.2018.11.008

Cite this

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title = "Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.",

abstract = "Malaria is an infectious disease, caused by Plasmodium parasites, that remains a major global health problem. Infection begins when salivary gland sporozoites are transmitted through the bite of an infected mosquito. Once within the host, sporozoites navigate through the dermis, into the bloodstream, and eventually invade hepatocytes. While we have an increasingly sophisticated cellular description of this journey, our molecular understanding of the extracellular interactions between the sporozoite and mammalian host that regulate migration and invasion remain comparatively poor. Here, we review the current state of our understanding, highlight the technical limitations that have frustrated progress, and outline how new approaches will help to address this knowledge gap with the ultimate aim of improving malaria treatments. Copyright {\textcopyright} 2018 Elsevier Ltd. All rights reserved.",

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AU - Sinnis, Photini

AU - Wright, Gavin J

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N2 - Malaria is an infectious disease, caused by Plasmodium parasites, that remains a major global health problem. Infection begins when salivary gland sporozoites are transmitted through the bite of an infected mosquito. Once within the host, sporozoites navigate through the dermis, into the bloodstream, and eventually invade hepatocytes. While we have an increasingly sophisticated cellular description of this journey, our molecular understanding of the extracellular interactions between the sporozoite and mammalian host that regulate migration and invasion remain comparatively poor. Here, we review the current state of our understanding, highlight the technical limitations that have frustrated progress, and outline how new approaches will help to address this knowledge gap with the ultimate aim of improving malaria treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.

AB - Malaria is an infectious disease, caused by Plasmodium parasites, that remains a major global health problem. Infection begins when salivary gland sporozoites are transmitted through the bite of an infected mosquito. Once within the host, sporozoites navigate through the dermis, into the bloodstream, and eventually invade hepatocytes. While we have an increasingly sophisticated cellular description of this journey, our molecular understanding of the extracellular interactions between the sporozoite and mammalian host that regulate migration and invasion remain comparatively poor. Here, we review the current state of our understanding, highlight the technical limitations that have frustrated progress, and outline how new approaches will help to address this knowledge gap with the ultimate aim of improving malaria treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.

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