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Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.

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JournalTrends in parasitology
DateE-pub ahead of print - 21 Dec 2018
DatePublished (current) - 1 Feb 2019
Issue number2
Volume35
Number of pages11
Pages (from-to)129-139
Early online date21/12/18
Original languageEnglish

Abstract

Malaria is an infectious disease, caused by Plasmodium parasites, that remains a major global health problem. Infection begins when salivary gland sporozoites are transmitted through the bite of an infected mosquito. Once within the host, sporozoites navigate through the dermis, into the bloodstream, and eventually invade hepatocytes. While we have an increasingly sophisticated cellular description of this journey, our molecular understanding of the extracellular interactions between the sporozoite and mammalian host that regulate migration and invasion remain comparatively poor. Here, we review the current state of our understanding, highlight the technical limitations that have frustrated progress, and outline how new approaches will help to address this knowledge gap with the ultimate aim of improving malaria treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.

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