Improving the hyperpolarization of (31)p nuclei by synthetic design

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Traditional (31)P NMR or MRI measurements suffer from low sensitivity relative to (1)H detection and consequently require longer scan times. We show here that hyperpolarization of (31)P nuclei through reversible interactions with parahydrogen can deliver substantial signal enhancements in a range of regioisomeric phosphonate esters containing a heteroaromatic motif which were synthesized in order to identify the optimum molecular scaffold for polarization transfer. A 3588-fold (31)P signal enhancement (2.34% polarization) was returned for a partially deuterated pyridyl substituted phosphonate ester. This hyperpolarization level is sufficient to allow single scan (31)P MR images of a phantom to be recorded at a 9.4 T observation field in seconds that have signal-to-noise ratios of up to 94.4 when the analyte concentration is 10 mM. In contrast, a 12 h 2048 scan measurement under standard conditions yields a signal-to-noise ratio of just 11.4. (31)P-hyperpolarized images are also reported from a 7 T preclinical scanner.

Original languageEnglish
Pages (from-to)5020-5027
Number of pages8
JournalJournal of Physical Chemistry B
Issue number15
Publication statusPublished - 26 Mar 2015

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Copyright © 2015 American Chemical Society. This is an author produced version of a paper published in Journal of Physical Chemistry B. Uploaded with permission from the publisher.

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