Abstract
Benzylic, allylic, propargylic and unactivated alcohols can be oxidised with activated manganese dioxide in the presence of N-methoxy-N-methyl-2-(triphenylphosphoranylidine)acetamide to generate directly the corresponding alpha,beta-unsaturated Weinreb amides. Elaboration of the resulting Weinreb amides is also described, in particular as part of a new route to analogues of the arachidonic acid metabolite 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid. (C) 2002 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 115-118 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 1 |
Publication status | Published - 1 Jan 2003 |
Keywords
- MANGANESE-DIOXIDE
- 5-OXO-ETE