Increasing Catalyst Efficiency in C−H Activation Catalysis

Tobias Gensch, Michael J. James, Toryn Dalton, Frank Glorius*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


C−H activation reactions with high catalyst turnover numbers are still very rare in the literature and 10 mol % is a common catalyst loading in this field. We offer a representative overview of efficient C−H activation catalysis to highlight this neglected aspect of catalysis development and inspire future effort towards more efficient C−H activation. Examples ranging from palladium catalysis, Cp*Rh III - and Cp*Co III -catalysis, the C−H borylation and silylation to methane C−H activation are presented. In these reactions, up to tens of thousands of catalyst turnovers have been observed.

Original languageEnglish
Pages (from-to)2296-2306
Number of pages11
JournalAngewandte Chemie - International Edition
Issue number9
Publication statusPublished - 23 Feb 2018

Bibliographical note

© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.


  • catalysis
  • C−H activation
  • methane
  • palladium
  • rhodium
  • turnover

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