Individual Participant Data Meta-Analysis

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Most systematic reviews are based on identifying reports of eligible studies and base their analyses on data presented in these reports, typically journal publications. This can lead to bias and imprecision if studies do not report their results, or report them in inconsistent or unhelpful ways. Collection of individual participant data (IPD) from every participant in every study may reduce these problems. Using IPD offers many advantages, including collaboration with study authors, allowing for more consistent and complete analyses of the data, and investigating the impact of individual-level covariates. However, collecting and managing IPD generally require considerable time and expertise. While many aspects of an IPD systematic review are similar to those of a standard systematic review, important differences include establishing the collaborations or access necessary to obtain IPD, managing and checking, and the statistical methods used for meta-analysis of the data.

Original languageEnglish
Title of host publicationSystematic Reviews in Health Research
Subtitle of host publicationMeta-Analysis in Context: Third Edition
EditorsMatthias Egger, Julian P. T. Higgins, George Davey Smith
PublisherJohn Wiley & Sons Inc.
Number of pages18
ISBN (Electronic)9781119099369
ISBN (Print)9781405160506
Publication statusPublished - 1 Jan 2022

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