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Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8

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Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8. / Meng, Yuan Xiang; Spira, Thomas J.; Bhat, Ganapati J.; Birch, Chris J.; Druce, Julian D.; Edlin, Brian R.; Edwards, Rosalind; Gunthel, Cliff; Newton, Robert; Stamey, Felicia R.; Wood, Charles; Pellett, Philip E.

In: VIROLOGY, Vol. 261, No. 1, 15.08.1999, p. 106-119.

Research output: Contribution to journalArticlepeer-review

Harvard

Meng, YX, Spira, TJ, Bhat, GJ, Birch, CJ, Druce, JD, Edlin, BR, Edwards, R, Gunthel, C, Newton, R, Stamey, FR, Wood, C & Pellett, PE 1999, 'Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8', VIROLOGY, vol. 261, no. 1, pp. 106-119. https://doi.org/10.1006/viro.1999.9853

APA

Meng, Y. X., Spira, T. J., Bhat, G. J., Birch, C. J., Druce, J. D., Edlin, B. R., Edwards, R., Gunthel, C., Newton, R., Stamey, F. R., Wood, C., & Pellett, P. E. (1999). Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8. VIROLOGY, 261(1), 106-119. https://doi.org/10.1006/viro.1999.9853

Vancouver

Meng YX, Spira TJ, Bhat GJ, Birch CJ, Druce JD, Edlin BR et al. Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8. VIROLOGY. 1999 Aug 15;261(1):106-119. https://doi.org/10.1006/viro.1999.9853

Author

Meng, Yuan Xiang ; Spira, Thomas J. ; Bhat, Ganapati J. ; Birch, Chris J. ; Druce, Julian D. ; Edlin, Brian R. ; Edwards, Rosalind ; Gunthel, Cliff ; Newton, Robert ; Stamey, Felicia R. ; Wood, Charles ; Pellett, Philip E. / Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8. In: VIROLOGY. 1999 ; Vol. 261, No. 1. pp. 106-119.

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@article{801165b118f5427ca4360500ced148ea,
title = "Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8",
abstract = "To study human herpesvirus 8 (HHV-8) transmission between individuals and in populations, we developed a system for genetic fingerprinting of HHV-8 strains based on variation in the HHV-8 K1, glycoprotein B (gB), and glycoprotein H (gH) genes. Using this system, we sequenced nearly the entire K1 gene (840 bp); two segments of the gB gene (open reading frame 8), totaling 813 bp; and a 702-bp segment of the gH gene (open reading frame 22) from blood and tissue samples obtained from 40 human immunodeficiency virus- infected and noninfected individuals, including those with Kaposi's sarcoma, primary effusion lymphoma, or Castleman's disease. The specimen collection was assembled from individuals living in diverse geographical locations, including the United States, Australia, New Zealand, Uganda, and Zambia. As reported by others, K1 was the most variable gene, with up to 16% variation at the nucleotide sequence level and up to 32% variation at the amino acid sequence level. Despite this extensive sequence variation, the K1 amino acid sequence contained 14 conserved cysteine sites, suggesting a conserved tertiary structure, gB and gH sequences were highly conserved, in most cases differing by <0.6% in pairwise comparisons. K1 was the most useful gene for strain discrimination, but the other genes enabled the discrimination of strains with identical K1 sequences. Individuals from diverse geographic locations were infected with four different HHV-8 genotypes; strains did not strictly segregate by continent of origin. The majority of HHV-8 strains from the United States and Europe were relatively closely related, whereas some strains identified from Uganda and Australia were phylogenetically distant. Genotype I strains were the most common and were found on three continents. Identical sequences were found in specimens obtained from different body sites and at different times from the same individual.",
author = "Meng, {Yuan Xiang} and Spira, {Thomas J.} and Bhat, {Ganapati J.} and Birch, {Chris J.} and Druce, {Julian D.} and Edlin, {Brian R.} and Rosalind Edwards and Cliff Gunthel and Robert Newton and Stamey, {Felicia R.} and Charles Wood and Pellett, {Philip E.}",
year = "1999",
month = aug,
day = "15",
doi = "10.1006/viro.1999.9853",
language = "English",
volume = "261",
pages = "106--119",
journal = "VIROLOGY",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8

AU - Meng, Yuan Xiang

AU - Spira, Thomas J.

AU - Bhat, Ganapati J.

AU - Birch, Chris J.

AU - Druce, Julian D.

AU - Edlin, Brian R.

AU - Edwards, Rosalind

AU - Gunthel, Cliff

AU - Newton, Robert

AU - Stamey, Felicia R.

AU - Wood, Charles

AU - Pellett, Philip E.

PY - 1999/8/15

Y1 - 1999/8/15

N2 - To study human herpesvirus 8 (HHV-8) transmission between individuals and in populations, we developed a system for genetic fingerprinting of HHV-8 strains based on variation in the HHV-8 K1, glycoprotein B (gB), and glycoprotein H (gH) genes. Using this system, we sequenced nearly the entire K1 gene (840 bp); two segments of the gB gene (open reading frame 8), totaling 813 bp; and a 702-bp segment of the gH gene (open reading frame 22) from blood and tissue samples obtained from 40 human immunodeficiency virus- infected and noninfected individuals, including those with Kaposi's sarcoma, primary effusion lymphoma, or Castleman's disease. The specimen collection was assembled from individuals living in diverse geographical locations, including the United States, Australia, New Zealand, Uganda, and Zambia. As reported by others, K1 was the most variable gene, with up to 16% variation at the nucleotide sequence level and up to 32% variation at the amino acid sequence level. Despite this extensive sequence variation, the K1 amino acid sequence contained 14 conserved cysteine sites, suggesting a conserved tertiary structure, gB and gH sequences were highly conserved, in most cases differing by <0.6% in pairwise comparisons. K1 was the most useful gene for strain discrimination, but the other genes enabled the discrimination of strains with identical K1 sequences. Individuals from diverse geographic locations were infected with four different HHV-8 genotypes; strains did not strictly segregate by continent of origin. The majority of HHV-8 strains from the United States and Europe were relatively closely related, whereas some strains identified from Uganda and Australia were phylogenetically distant. Genotype I strains were the most common and were found on three continents. Identical sequences were found in specimens obtained from different body sites and at different times from the same individual.

AB - To study human herpesvirus 8 (HHV-8) transmission between individuals and in populations, we developed a system for genetic fingerprinting of HHV-8 strains based on variation in the HHV-8 K1, glycoprotein B (gB), and glycoprotein H (gH) genes. Using this system, we sequenced nearly the entire K1 gene (840 bp); two segments of the gB gene (open reading frame 8), totaling 813 bp; and a 702-bp segment of the gH gene (open reading frame 22) from blood and tissue samples obtained from 40 human immunodeficiency virus- infected and noninfected individuals, including those with Kaposi's sarcoma, primary effusion lymphoma, or Castleman's disease. The specimen collection was assembled from individuals living in diverse geographical locations, including the United States, Australia, New Zealand, Uganda, and Zambia. As reported by others, K1 was the most variable gene, with up to 16% variation at the nucleotide sequence level and up to 32% variation at the amino acid sequence level. Despite this extensive sequence variation, the K1 amino acid sequence contained 14 conserved cysteine sites, suggesting a conserved tertiary structure, gB and gH sequences were highly conserved, in most cases differing by <0.6% in pairwise comparisons. K1 was the most useful gene for strain discrimination, but the other genes enabled the discrimination of strains with identical K1 sequences. Individuals from diverse geographic locations were infected with four different HHV-8 genotypes; strains did not strictly segregate by continent of origin. The majority of HHV-8 strains from the United States and Europe were relatively closely related, whereas some strains identified from Uganda and Australia were phylogenetically distant. Genotype I strains were the most common and were found on three continents. Identical sequences were found in specimens obtained from different body sites and at different times from the same individual.

UR - http://www.scopus.com/inward/record.url?scp=0033567151&partnerID=8YFLogxK

U2 - 10.1006/viro.1999.9853

DO - 10.1006/viro.1999.9853

M3 - Article

C2 - 10441559

AN - SCOPUS:0033567151

VL - 261

SP - 106

EP - 119

JO - VIROLOGY

JF - VIROLOGY

SN - 0042-6822

IS - 1

ER -