Infectious proxies and childhood leukaemia: Findings from the United Kingdom Childhood Cancer Study (UKCCS)

Research output: Contribution to journalArticle

Author(s)

Department/unit(s)

Publication details

JournalBlood cells molecules and diseases
DatePublished - Mar 2009
Issue number2
Volume42
Number of pages3
Pages (from-to)126-128
Original languageEnglish

Abstract

The United Kingdom Childhood Cancer Study (UKCCS) was specifically designed to investigate the potential etiological role of infections as one of its objectives and information on a number of markers of infectious exposure from multiple sources was collected (www.ukccs.org). This study found that a mother's recollections of past minor illness episodes in her children were unreliable, producing systematic case-control differences. From birth onwards children diagnosed with ALL between 2-5 years were found to have had more clinically diagnosed infectious illness episodes (not fewer) than unaffected children, with those with two or more neonatal infections being diagnosed with leukaemia around 7 months earlier than those with only one or none. The findings from these analyses and their implications for future research are reviewed and discussed in this paper. (c) 2008 Elsevier Inc. All rights reserved.

    Research areas

  • Infection, Greaves hypothesis, Socio-economic status, ACUTE LYMPHOBLASTIC-LEUKEMIA, DAY-CARE, SOCIOECONOMIC-STATUS, 1ST YEAR, RISK, PREGNANCY, MALIGNANCIES, ASSOCIATION, INFLUENZA, DISEASES

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations