Abstract
Our epithelium represents a battle ground against a variety of insults including pathogens and danger signals. It encodes multiple sensors that detect and respond to such insults, playing an essential role in maintaining and defending tissue homeostasis. One key set of defense mechanisms is our inflammasomes which drive innate immune responses including, sensing and responding to pathogen attack, through the secretion of pro-inflammatory cytokines and cell death. Identification of physiologically relevant triggers for inflammasomes has greatly influenced our ability to decipher the mechanisms behind inflammasome activation. Furthermore, identification of patient mutations within inflammasome components implicates their involvement in a range of epithelial diseases. This review will focus on exploring the roles of inflammasomes in epithelial immunity and cover: the diversity and differential expression of inflammasome sensors amongst our epithelial barriers, their ability to sense local infection and damage and the contribution of the inflammasomes to epithelial homeostasis and disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1335-1353 |
| Number of pages | 19 |
| Journal | FEBS Letters |
| Volume | 598 |
| Issue number | 11 |
| Early online date | 14 Mar 2024 |
| DOIs | |
| Publication status | Published - 10 Jun 2024 |
Bibliographical note
© 2024 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.Keywords
- Inflammasomes/immunology
- Humans
- Immunity, Innate
- Animals
- Epithelium/immunology
- Epithelial Cells/immunology
- Homeostasis/immunology