Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes

Connie Ross; Amy H Chan; Jessica B von Pein; Madhavi P Maddugoda; Dave Boucher; Kate Schroder

doi:10.1146/annurev-immunol-101220-030653

Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes

Connie Ross, Amy H Chan, Jessica B von Pein, Madhavi P Maddugoda, Dave Boucher, Kate Schroder

Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are inflammatory caspases activated by inflammasomes to drive lytic cell death and inflammatory mediator production, thereby activating host-protective and pathological immune responses. Here, we comprehensively review the mechanisms that govern the activity of inflammatory caspases. We discuss inflammatory caspase activation and deactivation mechanisms, alongside the physiological importance of caspase activity kinetics. We also examine mechanisms of caspase substrate selection and how inflammasome and cell identities influence caspase activity and resultant inflammatory and pyroptotic cellular programs. Understanding how inflammatory caspases are regulated may offer new strategies for treating infection and inflammasome-driven disease. Expected final online publication date for the Annual Review of Immunology, Volume 40 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Original language	English
Journal	Annual review of immunology
DOIs	https://doi.org/10.1146/annurev-immunol-101220-030653
Publication status	E-pub ahead of print - 26 Jan 2022

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10.1146/annurev-immunol-101220-030653

Cite this

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title = "Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes",

abstract = "Inflammasomes are inflammatory signaling complexes that provide molecular platforms to activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are inflammatory caspases activated by inflammasomes to drive lytic cell death and inflammatory mediator production, thereby activating host-protective and pathological immune responses. Here, we comprehensively review the mechanisms that govern the activity of inflammatory caspases. We discuss inflammatory caspase activation and deactivation mechanisms, alongside the physiological importance of caspase activity kinetics. We also examine mechanisms of caspase substrate selection and how inflammasome and cell identities influence caspase activity and resultant inflammatory and pyroptotic cellular programs. Understanding how inflammatory caspases are regulated may offer new strategies for treating infection and inflammasome-driven disease. Expected final online publication date for the Annual Review of Immunology, Volume 40 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.",

author = "Connie Ross and Chan, {Amy H} and {von Pein}, {Jessica B} and Maddugoda, {Madhavi P} and Dave Boucher and Kate Schroder",

year = "2022",

month = jan,

day = "26",

doi = "10.1146/annurev-immunol-101220-030653",

language = "English",

journal = "Annual review of immunology",

issn = "0732-0582",

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TY - JOUR

T1 - Inflammatory Caspases

T2 - Toward a Unified Model for Caspase Activation by Inflammasomes

AU - Ross, Connie

AU - Chan, Amy H

AU - von Pein, Jessica B

AU - Maddugoda, Madhavi P

AU - Boucher, Dave

AU - Schroder, Kate

PY - 2022/1/26

Y1 - 2022/1/26

N2 - Inflammasomes are inflammatory signaling complexes that provide molecular platforms to activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are inflammatory caspases activated by inflammasomes to drive lytic cell death and inflammatory mediator production, thereby activating host-protective and pathological immune responses. Here, we comprehensively review the mechanisms that govern the activity of inflammatory caspases. We discuss inflammatory caspase activation and deactivation mechanisms, alongside the physiological importance of caspase activity kinetics. We also examine mechanisms of caspase substrate selection and how inflammasome and cell identities influence caspase activity and resultant inflammatory and pyroptotic cellular programs. Understanding how inflammatory caspases are regulated may offer new strategies for treating infection and inflammasome-driven disease. Expected final online publication date for the Annual Review of Immunology, Volume 40 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

AB - Inflammasomes are inflammatory signaling complexes that provide molecular platforms to activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are inflammatory caspases activated by inflammasomes to drive lytic cell death and inflammatory mediator production, thereby activating host-protective and pathological immune responses. Here, we comprehensively review the mechanisms that govern the activity of inflammatory caspases. We discuss inflammatory caspase activation and deactivation mechanisms, alongside the physiological importance of caspase activity kinetics. We also examine mechanisms of caspase substrate selection and how inflammasome and cell identities influence caspase activity and resultant inflammatory and pyroptotic cellular programs. Understanding how inflammatory caspases are regulated may offer new strategies for treating infection and inflammasome-driven disease. Expected final online publication date for the Annual Review of Immunology, Volume 40 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

U2 - 10.1146/annurev-immunol-101220-030653

DO - 10.1146/annurev-immunol-101220-030653

M3 - Review article

C2 - 35080918

SN - 0732-0582

JO - Annual review of immunology

JF - Annual review of immunology

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