Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms

A J Tunbridge; T M Stevanin; M Lee; H M Marriott; J W B Moir; R C Read; D H Dockrell

doi:10.1128/IAI.74.1.729-733.2006

Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms

A J Tunbridge, T M Stevanin, M Lee, H M Marriott, J W B Moir, R C Read, D H Dockrell

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

Original language	English
Pages (from-to)	729-733
Number of pages	5
Journal	Infection and Immunity
Volume	74
Issue number	1
DOIs	https://doi.org/10.1128/IAI.74.1.729-733.2006
Publication status	Published - Jan 2006

Keywords

STREPTOCOCCUS-PNEUMONIAE
CELLS
PHAGOCYTOSIS
EXPRESSION
ACTIVATION
RECEPTORS
PROTEINS
SURVIVAL
MUCOSA
MCL-1

Access to Document

10.1128/IAI.74.1.729-733.2006

Cite this

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title = "Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms",

abstract = "Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.",

keywords = "STREPTOCOCCUS-PNEUMONIAE, CELLS, PHAGOCYTOSIS, EXPRESSION, ACTIVATION, RECEPTORS, PROTEINS, SURVIVAL, MUCOSA, MCL-1",

author = "Tunbridge, {A J} and Stevanin, {T M} and M Lee and Marriott, {H M} and Moir, {J W B} and Read, {R C} and Dockrell, {D H}",

year = "2006",

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T1 - Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms

AU - Tunbridge, A J

AU - Stevanin, T M

AU - Lee, M

AU - Marriott, H M

AU - Moir, J W B

AU - Read, R C

AU - Dockrell, D H

PY - 2006/1

Y1 - 2006/1

N2 - Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

AB - Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

KW - STREPTOCOCCUS-PNEUMONIAE

KW - CELLS

KW - PHAGOCYTOSIS

KW - EXPRESSION

KW - ACTIVATION

KW - RECEPTORS

KW - PROTEINS

KW - SURVIVAL

KW - MUCOSA

KW - MCL-1

U2 - 10.1128/IAI.74.1.729-733.2006

DO - 10.1128/IAI.74.1.729-733.2006

M3 - Article

SN - 1098-5522

VL - 74

SP - 729

EP - 733

JO - Infection and Immunity

JF - Infection and Immunity

IS - 1

ER -