Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor

Bhagavathy Shanmugasundaram, Aleksandra W. Debowski, Rebecca J. Dennis, Gideon J. Davies, David J. Vocadlo, Andrea Vasella

Research output: Contribution to journalArticlepeer-review

Abstract

Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.

Original languageEnglish
Pages (from-to)4372-4374
Number of pages3
JournalChemical Communications
Issue number42
DOIs
Publication statusPublished - 2006

Keywords

  • BETA-D-GLUCOSAMINIDASE
  • N-ACETYLGLUCOSAMINE
  • MECHANISM
  • GLYCOSIDASES
  • GLYCOSYLATION
  • INSIGHTS

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