By the same authors

From the same journal

Insights from structural studies of the cardiovirus 2A protein

Research output: Contribution to journalReview articlepeer-review

Full text download(s)

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalBioscience Reports
DateAccepted/In press - 10 Jan 2022
DatePublished (current) - 20 Jan 2022
Issue number1
Volume42
Number of pages12
Original languageEnglish

Abstract

Cardioviruses are single-stranded RNA viruses of the family Picornaviridae. In addition to being the first example of internal ribosome entry site (IRES) utilization, cardioviruses also employ a series of alternative translation strategies, such as Stop-Go translation and programmed ribosome frameshifting. Here, we focus on cardiovirus 2A protein, which is not only a primary virulence factor, but also exerts crucial regulatory functions during translation, including activation of viral ribosome frameshifting and inhibition of host cap-dependent translation. Only recently, biochemical and structural studies have allowed us to close the gaps in our knowledge of how cardiovirus 2A is able to act in diverse translation-related processes as a novel RNA-binding protein. This review will summarize these findings, which ultimately may lead to the discovery of other RNA-mediated gene expression strategies across a broad range of RNA viruses.

Bibliographical note

© 2022 The Author(s).

    Research areas

  • Cardiovirus/genetics, Internal Ribosome Entry Sites/genetics, Viral Proteins/genetics

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations