Insights into the Regulation of Gene Transfer Agent Production

Paul Christopher Michael Fogg

Insights into the Regulation of Gene Transfer Agent Production

Biology

Research output: Other contribution

Abstract

Gene Transfer Agents (GTAs) are similar to traditional viruses in many ways but, instead of prioritizing the spread of their own genes, they package and disseminate the entire genome of the bacterial host. Expression of the GTA genes is controlled by various host regulator proteins and release from the producer cell is achieved via lysis from within. Indiscriminate transfer of bacterial genes clearly has the potential to impact bacterial evolution, but there are large gaps in our knowledge of GTA biology.

Original language	English
Type	Nature Communications Behind the Paper
Media of output	Blog
Publisher	Springer
Publication status	Published - 5 Feb 2019

Access to Document

https://naturemicrobiologycommunity.nature.com/users/205474-paul-christopher-michael-fogg/posts/43457-gene-transfer-agentsLicence: Unspecified

Cite this

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abstract = "Gene Transfer Agents (GTAs) are similar to traditional viruses in many ways but, instead of prioritizing the spread of their own genes, they package and disseminate the entire genome of the bacterial host. Expression of the GTA genes is controlled by various host regulator proteins and release from the producer cell is achieved via lysis from within. Indiscriminate transfer of bacterial genes clearly has the potential to impact bacterial evolution, but there are large gaps in our knowledge of GTA biology.",

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AB - Gene Transfer Agents (GTAs) are similar to traditional viruses in many ways but, instead of prioritizing the spread of their own genes, they package and disseminate the entire genome of the bacterial host. Expression of the GTA genes is controlled by various host regulator proteins and release from the producer cell is achieved via lysis from within. Indiscriminate transfer of bacterial genes clearly has the potential to impact bacterial evolution, but there are large gaps in our knowledge of GTA biology.

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