Insulin structure and diabetes treatment

J Brange; J Whittingham; D Edwards; Z YouShang; A Wollmer; D Brandenburg; G Dodson; J Finch

Insulin structure and diabetes treatment

J Brange, J Whittingham, D Edwards, Z YouShang, A Wollmer, D Brandenburg, G Dodson, J Finch

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Insulin fibrils, formed by native and by monomeric molecules, have been prepared. When examined by electron microscopy they are indistinguishable. The packing of the monomeric insulin in the crystal lattice suggests how insulin fibres are constructed; the model explains the accelerated fibre formation by monomeric insulins and identifies mutations to probe the mechanism further.

Original language	English
Pages (from-to)	470-476
Number of pages	7
Journal	CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
Volume	72
Issue number	7
Publication status	Published - 10 Apr 1997

Keywords

DESPENTAPEPTIDE INSULIN
AQUEOUS-SOLUTIONS
REPLACEMENT
AGGREGATION
BINDING

Cite this

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title = "Insulin structure and diabetes treatment",

abstract = "Insulin fibrils, formed by native and by monomeric molecules, have been prepared. When examined by electron microscopy they are indistinguishable. The packing of the monomeric insulin in the crystal lattice suggests how insulin fibres are constructed; the model explains the accelerated fibre formation by monomeric insulins and identifies mutations to probe the mechanism further.",

keywords = "DESPENTAPEPTIDE INSULIN, AQUEOUS-SOLUTIONS, REPLACEMENT, AGGREGATION, BINDING",

author = "J Brange and J Whittingham and D Edwards and Z YouShang and A Wollmer and D Brandenburg and G Dodson and J Finch",

year = "1997",

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T1 - Insulin structure and diabetes treatment

AU - Brange, J

AU - Whittingham, J

AU - Edwards, D

AU - YouShang, Z

AU - Wollmer, A

AU - Brandenburg, D

AU - Dodson, G

AU - Finch, J

PY - 1997/4/10

Y1 - 1997/4/10

N2 - Insulin fibrils, formed by native and by monomeric molecules, have been prepared. When examined by electron microscopy they are indistinguishable. The packing of the monomeric insulin in the crystal lattice suggests how insulin fibres are constructed; the model explains the accelerated fibre formation by monomeric insulins and identifies mutations to probe the mechanism further.

AB - Insulin fibrils, formed by native and by monomeric molecules, have been prepared. When examined by electron microscopy they are indistinguishable. The packing of the monomeric insulin in the crystal lattice suggests how insulin fibres are constructed; the model explains the accelerated fibre formation by monomeric insulins and identifies mutations to probe the mechanism further.

KW - DESPENTAPEPTIDE INSULIN

KW - AQUEOUS-SOLUTIONS

KW - REPLACEMENT

KW - AGGREGATION

KW - BINDING

M3 - Article

VL - 72

SP - 470

EP - 476

JO - CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

JF - CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

IS - 7

ER -