By the same authors

From the same journal

Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19

Research output: Contribution to journalArticlepeer-review

Author(s)

  • Tobias Plowman
  • Katherine Newling
  • Christopher Jagger
  • Kara Filbey
  • Elizabeth Mann
  • Joanne Konkel
  • Madvi Menon
  • Sean Knight
  • Angela Simpson
  • CIRCO Collaborative Group
  • Aliyah Prihartadi
  • Greg Forshaw
  • Neil Todd
  • David Yates
  • John Grainger
  • Tracy Hussell

Department/unit(s)

Publication details

JournaliScience
DateAccepted/In press - 20 Dec 2021
DateE-pub ahead of print - 20 Dec 2021
DatePublished (current) - 21 Jan 2022
Issue number1
Volume25
Number of pages23
Early online date20/12/21
Original languageEnglish

Abstract

Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized COVID-19 patients (Cohort 1) and levels of 25 cytokines and chemokines (CC) in the same samples. Combining microRNA (miRNA) and CC measurements allowed for discrimination of severe cases with greater accuracy than using miRNA or CC levels alone. Severity group-specific associations between miRNAs and COVID-19-associated CC (e.g., IL6, CCL20) or clinical hallmarks of COVID-19 (e.g., neutrophilia, hypoalbuminemia) separated patients with similar CC levels but different disease severity. Analysis of an independent cohort of 108 patients from a different center (Cohort 2) demonstrated feasibility of CC/miRNA profiling in leftover hospital blood samples with similar severe disease CC and miRNA profiles, and revealed CCL20, IL6, IL10, and miR-451a as key correlates of fatal COVID-19. These findings highlight that systemic miRNA/CC networks underpin severe COVID-19.

Bibliographical note

© 2021 The Author(s)

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