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Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • L. S. Wakschlag
  • E. O. Kistner
  • D. S. Pine
  • G. Biesecker
  • K. E. Pickett
  • A. D. Skol
  • V. Dukic
  • R. J. R. Blair
  • B. L. Leventhal
  • N. J. Cox
  • J. L. Burns
  • K. E. Kasza
  • R. J. Wright
  • E. H. Cook

Department/unit(s)

Publication details

JournalMolecular psychiatry
DatePublished - Sep 2010
Issue number9
Volume15
Number of pages10
Pages (from-to)928-937
Original languageEnglish

Abstract

Genetic susceptibility to antisocial behavior may increase fetal sensitivity to prenatal exposure to cigarette smoke. Testing putative gene x exposure mechanisms requires precise measurement of exposure and outcomes. We tested whether a functional polymorphism in the gene encoding the enzyme monoamine oxidase A (MAOA) interacts with exposure to predict pathways to adolescent antisocial behavior. We assessed both clinical and information-processing outcomes. One hundred seventy-six adolescents and their mothers participated in a follow-up of a pregnancy cohort with well-characterized exposure. A sex-specific pattern of gene x exposure interaction was detected. Exposed boys with the low-activity MAOA 5' uVNTR (untranslated region variable number of tandem repeats) genotype were at increased risk for conduct disorder (CD) symptoms. In contrast, exposed girls with the high-activity MAOA uVNTR genotype were at increased risk for both CD symptoms and hostile attribution bias on a face-processing task. There was no evidence of a gene-environment correlation (rGE). Findings suggest that the MAOA uVNTR genotype, prenatal exposure to cigarettes and sex interact to predict antisocial behavior and related information-processing patterns. Future research to replicate and extend these findings should focus on elucidating how gene x exposure interactions may shape behavior through associated changes in brain function. Molecular Psychiatry (2010) 15, 928-937; doi:10.1038/mp.2009.22; published online 3 March 2009

    Research areas

  • prenatal smoking, MAOA, gene x environment interaction, developmental psychopathology, DEFICIT HYPERACTIVITY DISORDER, DOPAMINE TRANSPORTER GENOTYPE, GENE-ENVIRONMENT INTERACTION, MATERNAL SMOKING, MONOAMINE-OXIDASE, DEVELOPMENTAL PSYCHOPATHOLOGY, FUNCTIONAL POLYMORPHISM, EXTERNALIZING PROBLEMS, INDIVIDUAL-DIFFERENCES, LUNG-FUNCTION

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