Abstract
The effect of a radio-frequency driven, microscale non thermal atmospheric pressure plasma jet operated in helium with vol. 0.3% molecular oxygen gas admixture, on PC-3 prostate cancer cells has been investigated. The viability of cells exposed to the plasma was found to decrease with increasing plasma exposure time, with apoptosis through caspase and PARP cleavage being observed. High concentrations of nitrite and nitrate were detected in growth media exposed to the plasma and were found to increase in a time dependent manner post exposure. This indicates a slow release of reactive nitrogen species into the growth media, which is likely to influence cellular response to plasma exposure.
| Original language | English |
|---|---|
| Pages (from-to) | 1142-1149 |
| Number of pages | 8 |
| Journal | Plasma Processes and Polymers |
| Volume | 11 |
| Issue number | 12 |
| Early online date | 12 Sept 2014 |
| DOIs | |
| Publication status | Published - 8 Dec 2014 |
Keywords
- Apoptosis
- Cancer
- Nitric oxide
- Plasma jet
- Radicals
