Introducing an amine group to calix[5]arene: Comparison of several methods

Ondrej Kundrat*, Petr Slavik, Jiri Miksatko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Chemists often use an amine group as an intermediate in syntheses of imines, amides and ureas; however, in the case of syntheses of p-aminophenol type compounds, several problems might occur. In this article, we prepared p-aminocalix[5]arene-pentaol by reduction of both nitro and azo derivatives, and compared four methods of the amine preparation, focusing mainly on its gramme scale and time-consuming issues.

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalSupramolecular Chemistry
Issue number5-6
Early online date11 Dec 2015
Publication statusPublished - 2 Jun 2016


  • amine
  • azo coupling
  • Calixarene
  • nitration

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