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In addition to the main chromosome, approximately one in ten bacterial genomes have a 'second chromosome' or 'megaplasmid'. Here, we propose that these represent a single class of elements that have a distinct and consistent set of properties, and suggest the term 'chromid' to distinguish them from both chromosomes and plasmids. Chromids carry some core genes, and their nucleotide composition and codon usage are very similar to those of the chromosomes they are associated with. By contrast, they have plasmid replication and partitioning systems and the majority of their genes confer accessory functions. Chromids seem particularly rich in genus-specific genes and appear to be 'reinvented' at the origin of a new genus.
|Number of pages||8|
|Journal||Trends in microbiology|
|Publication status||Published - Apr 2010|
Bibliographical noteAlthough tagged as an "Opinion", this article proposes a novel concept based on comprehensive original bioinformatics research that is reported for the first time in this article and made up a significant part of the first author's PhD thesis.
- UNIQUE CIRCULAR CHROMOSOMES
- SYNONYMOUS CODON USAGE
- 1 Finished
Population genomics of bacteria
NATURAL ENVIRONMENT RESEARCH COUNCIL
1/11/06 → 31/12/10
Project: Research project (funded) › Research