Investigating mirror system (MS) activity in adults with ASD when inferring others' intentions using both TMS and EEG

Eleanor Jane Cole; Nicholas Edward Barraclough; Peter G. Enticott

Investigating mirror system (MS) activity in adults with ASD when inferring others' intentions using both TMS and EEG

Eleanor Jane Cole, Nicholas Edward Barraclough, Peter G. Enticott

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

ASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others’ intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8–10 Hz) suppression when mentalizing. Higher left mu (8–10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.

Original language	English
Number of pages	18
Journal	Journal of Autism and Developmental Disorders
Early online date	16 Feb 2018
Publication status	E-pub ahead of print - 16 Feb 2018

Bibliographical note

Keywords

AUTISM
ASD
MIRROR NEURONS
mentalizing
TMS
EEG
Electroencephalography (EEG)
TRANSCRANIAL MAGNETIC STIMULATION
INTENTIONS
AUTISM SPECTRUM DISORDERS
PERCEPTION

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s10803-018-3492-2
© The Author(s) 2018.
Final published version, 1.24 MBLicence: CC BY

Cite this

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title = "Investigating mirror system (MS) activity in adults with ASD when inferring others' intentions using both TMS and EEG",

abstract = "ASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others{\textquoteright} intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8–10 Hz) suppression when mentalizing. Higher left mu (8–10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.",

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author = "Cole, {Eleanor Jane} and Barraclough, {Nicholas Edward} and Enticott, {Peter G.}",

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AU - Cole, Eleanor Jane

AU - Barraclough, Nicholas Edward

AU - Enticott, Peter G.

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PY - 2018/2/16

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N2 - ASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others’ intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8–10 Hz) suppression when mentalizing. Higher left mu (8–10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.

AB - ASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others’ intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8–10 Hz) suppression when mentalizing. Higher left mu (8–10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.

KW - AUTISM

KW - ASD

KW - MIRROR NEURONS

KW - mentalizing

KW - TMS

KW - EEG

KW - Electroencephalography (EEG)

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - INTENTIONS

KW - AUTISM SPECTRUM DISORDERS

KW - PERCEPTION

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M3 - Article

SN - 0162-3257

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

ER -

Investigating mirror system (MS) activity in adults with ASD when inferring others' intentions using both TMS and EEG

Abstract

Bibliographical note

Keywords

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