Investigation of Parameters that Affect Resin Swelling in Green Solvents

Chidi Amadi-Kamalu, Holly Clarke, Matthew McRobie, James Mortimer, Michael North*, Yanrui Ran, Anne Routledge, Dani Sibbald, Matthew Tickias, Kai Tse, Helen Willway

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

Original languageEnglish
Pages (from-to)431-441
Number of pages11
Issue number4
Publication statusPublished - 3 Apr 2020

Bibliographical note

© 2020, The Author(s).


  • ChemMatrix
  • peptide
  • polystyrene
  • solvent
  • swelling

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