Investigation of Parameters that Affect Resin Swelling in Green Solvents

Chidi Amadi-Kamalu; Holly Clarke; Matthew McRobie; James Mortimer; Michael North; Yanrui Ran; Anne Routledge; Dani Sibbald; Matthew Tickias; Kai Tse; Helen Willway

doi:10.1002/open.202000030

Investigation of Parameters that Affect Resin Swelling in Green Solvents

Chidi Amadi-Kamalu, Holly Clarke, Matthew McRobie, James Mortimer, Michael North^*, Yanrui Ran, Anne Routledge, Dani Sibbald, Matthew Tickias, Kai Tse, Helen Willway

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

Original language	English
Pages (from-to)	431-441
Number of pages	11
Journal	ChemistryOpen
Volume	9
Issue number	4
DOIs	https://doi.org/10.1002/open.202000030 https://doi.org/10.1002/open.202000030
Publication status	Published - 3 Apr 2020

Bibliographical note

Keywords

ChemMatrix
peptide
polystyrene
solvent
swelling

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open.202000030
© 2020, The Author(s).
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abstract = "The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.",

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AU - Amadi-Kamalu, Chidi

AU - Clarke, Holly

AU - McRobie, Matthew

AU - Mortimer, James

AU - North, Michael

AU - Ran, Yanrui

AU - Routledge, Anne

AU - Sibbald, Dani

AU - Tickias, Matthew

AU - Tse, Kai

AU - Willway, Helen

PY - 2020/4/3

Y1 - 2020/4/3

N2 - The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

AB - The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

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KW - polystyrene

KW - solvent

KW - swelling

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Investigation of Parameters that Affect Resin Swelling in Green Solvents

Abstract

Bibliographical note

Keywords

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