Ionic modulation of immune checkpoint proteins

Research output: Contribution to conferenceOtherpeer-review


Despite extensive basic and clinical research on immune checkpoint regulatory pathways, little is known about the effects of the ionic tumour microenvironment on immune checkpoint expression and function. We screened effects of ion channel modulating compounds on indoleamine-2',3'-dioxygenase (IDO1) activity. Here, we describe a mechanistic link between Na+/K+ ATPase inhibition by cardiac glycosides and activity of IDO1, a well-characterized immune checkpoint. IDO1 catalyses the rate-limitig step of tryptophan catabolim and inhibits the immune response to the tumour by local depletion of tryptophan, an amino acid essential for anabolic functions in cancer and T cells.
Original languageEnglish
PagesProc Physiol Soc 43, C044
Publication statusPublished - 19 Jun 2019
EventPhysiology 2019 - Aberdeen Conference Centre, Aberdeen, United Kingdom
Duration: 7 Jul 201910 Jul 2019


ConferencePhysiology 2019
Country/TerritoryUnited Kingdom

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