Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni

P G Fallon; J Gibbons; R A Vervenne; E J Richardson; A J C Fulford; S Kiarie; R F Sturrock; P S Coulson; A M Deelder; J A M Langermans; A W Thomas; D W Dunne

Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni

P G Fallon, J Gibbons, R A Vervenne, E J Richardson, A J C Fulford, S Kiarie, R F Sturrock, P S Coulson, A M Deelder, J A M Langermans, A W Thomas, D W Dunne

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Adults and children have differences in their susceptibility to schistosomiasis. The relative influences of age-dependent innate resistance and acquired immunity in the differences between susceptibility to schistosomiasis are difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. In contrast to the adult animals, the juvenile rhesus monkeys had low levels of interleukin (IL)-4 and IL-5 production by peripheral blood mononuclear cells after schistosome infection, as well as lower levels of parasite-antigen-specific antibody (IgG, IgM, and IgA) responses, and produced limited antigen-specific or total IgE. Juvenile animals had statistically nonsignificant increased worm burdens and tissue or fecal egg counts, compared with that of adults, whereas circulating schistosome antigens were significantly higher in infected juvenile monkeys. These results suggest that juvenile rhesus monkeys have reduced type 2 cytokine responses after primary schistosome infections and perhaps are more susceptible to parasite infection.

Original language	English
Pages (from-to)	939-945
Number of pages	7
Journal	The Journal of Infectious Diseases
Volume	187
Issue number	6
Publication status	Published - 15 Mar 2003

Keywords

WORM ANTIGENS
HUMAN RESISTANCE
REINFECTION
IMMUNITY
IGE
ASSOCIATION
HAEMATOBIUM
MICE
AGE
SULFATE

Cite this

Fallon, P. G., Gibbons, J., Vervenne, R. A., Richardson, E. J., Fulford, A. J. C., Kiarie, S., Sturrock, R. F., Coulson, P. S., Deelder, A. M., Langermans, J. A. M., Thomas, A. W., & Dunne, D. W. (2003). Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni. The Journal of Infectious Diseases, 187(6), 939-945.

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title = "Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni",

abstract = "Adults and children have differences in their susceptibility to schistosomiasis. The relative influences of age-dependent innate resistance and acquired immunity in the differences between susceptibility to schistosomiasis are difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. In contrast to the adult animals, the juvenile rhesus monkeys had low levels of interleukin (IL)-4 and IL-5 production by peripheral blood mononuclear cells after schistosome infection, as well as lower levels of parasite-antigen-specific antibody (IgG, IgM, and IgA) responses, and produced limited antigen-specific or total IgE. Juvenile animals had statistically nonsignificant increased worm burdens and tissue or fecal egg counts, compared with that of adults, whereas circulating schistosome antigens were significantly higher in infected juvenile monkeys. These results suggest that juvenile rhesus monkeys have reduced type 2 cytokine responses after primary schistosome infections and perhaps are more susceptible to parasite infection.",

keywords = "WORM ANTIGENS, HUMAN RESISTANCE, REINFECTION, IMMUNITY, IGE, ASSOCIATION, HAEMATOBIUM, MICE, AGE, SULFATE",

author = "Fallon, {P G} and J Gibbons and Vervenne, {R A} and Richardson, {E J} and Fulford, {A J C} and S Kiarie and Sturrock, {R F} and Coulson, {P S} and Deelder, {A M} and Langermans, {J A M} and Thomas, {A W} and Dunne, {D W}",

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T1 - Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni

AU - Fallon, P G

AU - Gibbons, J

AU - Vervenne, R A

AU - Richardson, E J

AU - Fulford, A J C

AU - Kiarie, S

AU - Sturrock, R F

AU - Coulson, P S

AU - Deelder, A M

AU - Langermans, J A M

AU - Thomas, A W

AU - Dunne, D W

PY - 2003/3/15

Y1 - 2003/3/15

N2 - Adults and children have differences in their susceptibility to schistosomiasis. The relative influences of age-dependent innate resistance and acquired immunity in the differences between susceptibility to schistosomiasis are difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. In contrast to the adult animals, the juvenile rhesus monkeys had low levels of interleukin (IL)-4 and IL-5 production by peripheral blood mononuclear cells after schistosome infection, as well as lower levels of parasite-antigen-specific antibody (IgG, IgM, and IgA) responses, and produced limited antigen-specific or total IgE. Juvenile animals had statistically nonsignificant increased worm burdens and tissue or fecal egg counts, compared with that of adults, whereas circulating schistosome antigens were significantly higher in infected juvenile monkeys. These results suggest that juvenile rhesus monkeys have reduced type 2 cytokine responses after primary schistosome infections and perhaps are more susceptible to parasite infection.

AB - Adults and children have differences in their susceptibility to schistosomiasis. The relative influences of age-dependent innate resistance and acquired immunity in the differences between susceptibility to schistosomiasis are difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. In contrast to the adult animals, the juvenile rhesus monkeys had low levels of interleukin (IL)-4 and IL-5 production by peripheral blood mononuclear cells after schistosome infection, as well as lower levels of parasite-antigen-specific antibody (IgG, IgM, and IgA) responses, and produced limited antigen-specific or total IgE. Juvenile animals had statistically nonsignificant increased worm burdens and tissue or fecal egg counts, compared with that of adults, whereas circulating schistosome antigens were significantly higher in infected juvenile monkeys. These results suggest that juvenile rhesus monkeys have reduced type 2 cytokine responses after primary schistosome infections and perhaps are more susceptible to parasite infection.

KW - WORM ANTIGENS

KW - HUMAN RESISTANCE

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KW - IMMUNITY

KW - IGE

KW - ASSOCIATION

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KW - MICE

KW - AGE

KW - SULFATE

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JO - The Journal of Infectious Diseases

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