Knee Replacement Bandaging Study (KReBS) Evaluating the effect of a Two-layer Compression Bandage System on Knee Function following Total Knee Arthroplasty: Study Protocol for a Randomised Controlled Trial

Elizabeth Cook, Matthew Northgraves, Caroline Marie Fairhurst, Sarah Jane Ronaldson, David John Torgerson, Jonathan Kent, Mike Reed

Research output: Contribution to journalArticlepeer-review


Data from a feasibility study suggests that the use of an inelastic, short-stretch compression bandage following total knee arthroplasty is a safe technique that may improve patient reported health outcomes, and that it is feasible to recruit to a full-scale study.

We will conduct a randomised controlled trial (RCT) of 2600 adult patients, which has 80% power to detect a 1 point difference in the Oxford Knee Score (a patient self-reported assessment of knee pain and function) at 52 weeks. Short stretch compression bandaging will be compared with standard wool and crepe bandaging following total knee arthroplasty. Recruitment will take place in orthopaedic units across the United Kingdom. Secondary outcomes include the EQ-5D-5L and EQ-5D-3L scores, pain, length of hospital stay and complications.

The KReBS trial is a large study which aims to contribute to the evidence-base for informing clinical decisions for the use of compression bandaging following knee arthroplasty.

Trial registration
The trial is registered with the International Standard Randomised Controlled Trial Register (ISRCTN 87127065). Date of registration was 20/02/2017 (

Knee replacement; arthroplasty; compression bandage; randomised controlled trial
Original languageEnglish
Number of pages9
Issue number261
Publication statusPublished - 8 May 2019

Bibliographical note

© The Author(s). 2019

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