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Knockout tissue models - targeted gene disruption in three dimensions

Research output: Contribution to specialist publicationArticle

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Knockout tissue models - targeted gene disruption in three dimensions. / Carstairs, Alice; Marshall, Julia; Genever, Paul.

In: The Biochemist, Vol. 36, No. 3, 06.2014, p. 14-18.

Research output: Contribution to specialist publicationArticle

Harvard

Carstairs, A, Marshall, J & Genever, P 2014, 'Knockout tissue models - targeted gene disruption in three dimensions' The Biochemist, vol. 36, no. 3, pp. 14-18.

APA

Carstairs, A., Marshall, J., & Genever, P. (2014). Knockout tissue models - targeted gene disruption in three dimensions. The Biochemist, 36(3), 14-18.

Vancouver

Carstairs A, Marshall J, Genever P. Knockout tissue models - targeted gene disruption in three dimensions. The Biochemist. 2014 Jun;36(3):14-18.

Author

Carstairs, Alice ; Marshall, Julia ; Genever, Paul. / Knockout tissue models - targeted gene disruption in three dimensions. In: The Biochemist. 2014 ; Vol. 36, No. 3. pp. 14-18.

Bibtex - Download

@misc{4808cb55af254fc1bf983320bfda2f40,
title = "Knockout tissue models - targeted gene disruption in three dimensions",
abstract = "The use of animal studies in scientific research is increasing, mostly attributed to the rising requirement for genetically modified animals. In 2012, 4.11 million animal procedures were conducted within the UK, the majority of which involved genetically modified animals; a first since records began. Although animal models bring clear scientific insight, they have their limitations and alternative research methods are actively sought. The development of new targeted gene disruption technologies, such as transcription activator- like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR), combined with innovative 3D human cell culture methods can provide an attractive in vitro alternative.",
author = "Alice Carstairs and Julia Marshall and Paul Genever",
year = "2014",
month = "6",
language = "English",
volume = "36",
pages = "14--18",
journal = "The Biochemist",
issn = "0954-982X",
publisher = "Portland Press Ltd.",

}

RIS (suitable for import to EndNote) - Download

TY - GEN

T1 - Knockout tissue models - targeted gene disruption in three dimensions

AU - Carstairs, Alice

AU - Marshall, Julia

AU - Genever, Paul

PY - 2014/6

Y1 - 2014/6

N2 - The use of animal studies in scientific research is increasing, mostly attributed to the rising requirement for genetically modified animals. In 2012, 4.11 million animal procedures were conducted within the UK, the majority of which involved genetically modified animals; a first since records began. Although animal models bring clear scientific insight, they have their limitations and alternative research methods are actively sought. The development of new targeted gene disruption technologies, such as transcription activator- like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR), combined with innovative 3D human cell culture methods can provide an attractive in vitro alternative.

AB - The use of animal studies in scientific research is increasing, mostly attributed to the rising requirement for genetically modified animals. In 2012, 4.11 million animal procedures were conducted within the UK, the majority of which involved genetically modified animals; a first since records began. Although animal models bring clear scientific insight, they have their limitations and alternative research methods are actively sought. The development of new targeted gene disruption technologies, such as transcription activator- like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR), combined with innovative 3D human cell culture methods can provide an attractive in vitro alternative.

M3 - Article

VL - 36

SP - 14

EP - 18

JO - The Biochemist

JF - The Biochemist

SN - 0954-982X

ER -