Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

K. A. Pettigrew; S. F. Fajutrao Valles; K. Moll; K. Northstone; S. Ring; C. Pennell; C. Wang; R. Leavett; M. E. Hayiou-Thomas; P. Thompson; N. H. Simpson; S. E. Fisher; D. F. Newbury; R. Nudel; A. P. Monaco; S. E. Fisher; C. Francks; G. Baird; V. Slonims; K. Dworzynski; P. F. Bolton; E. Simonoff; A. O'Hare; J. Seckl; H. Cowie; A. Clark; J. Watson; J. Nasir; W. Cohen; A. Everitt; E. R. Hennessy; D. Shaw; P. J. Helms; Z. Simkin; G. Conti; D. Ramsden; D. V M Bishop; A. Pickles; A. J O Whitehouse; M. J. Snowling; S. Paracchini; SLI Consortium The SLI Consortium

doi:10.1111/gbb.12213

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

K. A. Pettigrew, S. F. Fajutrao Valles, K. Moll, K. Northstone, S. Ring, C. Pennell, C. Wang, R. Leavett, M. E. Hayiou-Thomas, P. Thompson, N. H. Simpson, S. E. Fisher, D. F. Newbury, R. Nudel, A. P. Monaco, S. E. Fisher, C. Francks, G. Baird, V. Slonims, K. DworzynskiP. F. Bolton, E. Simonoff, A. O'Hare, J. Seckl, H. Cowie, A. Clark, J. Watson, J. Nasir, W. Cohen, A. Everitt, E. R. Hennessy, D. Shaw, P. J. Helms, Z. Simkin, G. Conti, D. Ramsden, D. V M Bishop, A. Pickles, A. J O Whitehouse, M. J. Snowling, S. Paracchini^*, SLI Consortium The SLI Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

Original language	English
Pages (from-to)	369-376
Number of pages	8
Journal	Genes brain and behavior
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/gbb.12213
Publication status	Published - 1 Jan 2015

Keywords

ALSPAC
Cognitive abilities
Dyscalculia
Dyslexia
Genetic association
Neurodevelopmental disorders

Access to Document

10.1111/gbb.12213

Cite this

Pettigrew, K. A., Fajutrao Valles, S. F., Moll, K., Northstone, K., Ring, S., Pennell, C., Wang, C., Leavett, R., Hayiou-Thomas, M. E., Thompson, P., Simpson, N. H., Fisher, S. E., Newbury, D. F., Nudel, R., Monaco, A. P., Fisher, S. E., Francks, C., Baird, G., Slonims, V., ... The SLI Consortium, SLI. C. (2015). Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. Genes brain and behavior, 14(4), 369-376. https://doi.org/10.1111/gbb.12213

@article{84cccb000c3b4c56bb916701ed2915d8,

title = "Lack of replication for the myosin-18B association with mathematical ability in independent cohorts",

abstract = "Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.",

keywords = "ALSPAC, Cognitive abilities, Dyscalculia, Dyslexia, Genetic association, Neurodevelopmental disorders",

author = "Pettigrew, {K. A.} and {Fajutrao Valles}, {S. F.} and K. Moll and K. Northstone and S. Ring and C. Pennell and C. Wang and R. Leavett and Hayiou-Thomas, {M. E.} and P. Thompson and Simpson, {N. H.} and Fisher, {S. E.} and Newbury, {D. F.} and R. Nudel and Monaco, {A. P.} and Fisher, {S. E.} and C. Francks and G. Baird and V. Slonims and K. Dworzynski and Bolton, {P. F.} and E. Simonoff and A. O'Hare and J. Seckl and H. Cowie and A. Clark and J. Watson and J. Nasir and W. Cohen and A. Everitt and Hennessy, {E. R.} and D. Shaw and Helms, {P. J.} and Z. Simkin and G. Conti and D. Ramsden and Bishop, {D. V M} and A. Pickles and Whitehouse, {A. J O} and Snowling, {M. J.} and S. Paracchini and {The SLI Consortium}, {SLI Consortium}",

year = "2015",

month = jan,

day = "1",

doi = "10.1111/gbb.12213",

language = "English",

volume = "14",

pages = "369--376",

journal = "Genes brain and behavior",

issn = "1601-1848",

publisher = "Wiley-Blackwell",

number = "4",

}

Pettigrew, KA, Fajutrao Valles, SF, Moll, K, Northstone, K, Ring, S, Pennell, C, Wang, C, Leavett, R, Hayiou-Thomas, ME , Thompson, P, Simpson, NH, Fisher, SE, Newbury, DF, Nudel, R, Monaco, AP, Fisher, SE, Francks, C, Baird, G, Slonims, V, Dworzynski, K, Bolton, PF, Simonoff, E, O'Hare, A, Seckl, J, Cowie, H, Clark, A, Watson, J, Nasir, J, Cohen, W, Everitt, A, Hennessy, ER, Shaw, D, Helms, PJ, Simkin, Z, Conti, G, Ramsden, D, Bishop, DVM, Pickles, A, Whitehouse, AJO, Snowling, MJ, Paracchini, S & The SLI Consortium, SLIC 2015, 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts', Genes brain and behavior, vol. 14, no. 4, pp. 369-376. https://doi.org/10.1111/gbb.12213

TY - JOUR

T1 - Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

AU - Pettigrew, K. A.

AU - Fajutrao Valles, S. F.

AU - Moll, K.

AU - Northstone, K.

AU - Ring, S.

AU - Pennell, C.

AU - Wang, C.

AU - Leavett, R.

AU - Hayiou-Thomas, M. E.

AU - Thompson, P.

AU - Simpson, N. H.

AU - Fisher, S. E.

AU - Newbury, D. F.

AU - Nudel, R.

AU - Monaco, A. P.

AU - Fisher, S. E.

AU - Francks, C.

AU - Baird, G.

AU - Slonims, V.

AU - Dworzynski, K.

AU - Bolton, P. F.

AU - Simonoff, E.

AU - O'Hare, A.

AU - Seckl, J.

AU - Cowie, H.

AU - Clark, A.

AU - Watson, J.

AU - Nasir, J.

AU - Cohen, W.

AU - Everitt, A.

AU - Hennessy, E. R.

AU - Shaw, D.

AU - Helms, P. J.

AU - Simkin, Z.

AU - Conti, G.

AU - Ramsden, D.

AU - Bishop, D. V M

AU - Pickles, A.

AU - Whitehouse, A. J O

AU - Snowling, M. J.

AU - Paracchini, S.

AU - The SLI Consortium, SLI Consortium

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

AB - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

KW - ALSPAC

KW - Cognitive abilities

KW - Dyscalculia

KW - Dyslexia

KW - Genetic association

KW - Neurodevelopmental disorders

UR - http://www.scopus.com/inward/record.url?scp=84928304900&partnerID=8YFLogxK

U2 - 10.1111/gbb.12213

DO - 10.1111/gbb.12213

M3 - Article

AN - SCOPUS:84928304900

SN - 1601-1848

VL - 14

SP - 369

EP - 376

JO - Genes brain and behavior

JF - Genes brain and behavior

IS - 4

ER -

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

Abstract

Keywords

Access to Document

Other files and links

Cite this