Language and reading impairments are associated with increased prevalence of non-right-handedness

Filippo Abbondanza; Philip S. Dale; Carol A.  Wang; Emma Hayiou-Thomas; Umar Toseeb; Tanner S  Koomar; Karen G Wigg; Yu Feng; Kaitlyn M Price; Elizabeth Kerr; Sharon L Guger; Maureen W Lovett; Lisa J Strug; Elsje van Bergen; Conor V.  Dolan; J Bruce  Tomblin; Kristina Moll; Gerd Schulte-Körne; Nina  Neuhoff; Andreas Warnke; Simon E. Fisher; Cathy L Barr; Jacob J Michaelson; Dorret I. Boomsma; Margaret Jean Snowling; Charles  Hulme; Andrew J.O. Whitehouse; Craig E Pennell; Dianne F Newbury; John Stein; Joel B. Talcott; Dorothy V. M. Bishop; Silvia Paracchini

doi:10.1111/cdev.13914

Language and reading impairments are associated with increased prevalence of non-right-handedness

Filippo Abbondanza, Philip S. Dale, Carol A. Wang, Emma Hayiou-Thomas, Umar Toseeb, Tanner S Koomar, Karen G Wigg, Yu Feng, Kaitlyn M Price, Elizabeth Kerr, Sharon L Guger, Maureen W Lovett, Lisa J Strug, Elsje van Bergen, Conor V. Dolan, J Bruce Tomblin, Kristina Moll, Gerd Schulte-Körne, Nina Neuhoff, Andreas WarnkeSimon E. Fisher, Cathy L Barr, Jacob J Michaelson, Dorret I. Boomsma, Margaret Jean Snowling, Charles Hulme, Andrew J.O. Whitehouse, Craig E Pennell, Dianne F Newbury, John Stein, Joel B. Talcott, Dorothy V. M. Bishop, Silvia Paracchini

Research output: Contribution to journal › Article › peer-review

Abstract

Worldwide, the majority of people prefer using the right hand for most motor tasks. Because of the link between handedness and language hemispheric dominance, handedness has been studied for association with language-related disorders. No clear pattern has emerged from these studies, and inconsistencies have been attributed to small sample sizes, publication bias, and heterogeneous criteria for the definition of handedness and disorders.

Here, we assessed the frequency of non-right handedness (NRH) in 10 distinct cohorts not analysed before in this context. We identified N = 2,528 cases with reading and/or language impairment and N = 3,050 unique controls on the basis of a priori defined criteria. Overall, NRH was more frequent and more variable in the cases (8-24%) than in the controls (8-16%). Meta-analysis in the eight cohorts that met the inclusion criteria showed an increase of NRH in individuals with language/reading impairment compared to controls (OR = 1.21, CI = 1.03 - 1.44, p = 0.025). No moderator effects were detected for type of cohort (epidemiological versus clinical) and type of impairment (language versus reading).

Our results support an association between NRH and reading and language impairments which could result from shared biological pathways underlying brain lateralization, handedness, and cognitive functions

Original language	English
Pages (from-to)	970-984
Number of pages	15
Journal	Child Development
Volume	94
Issue number	4
Early online date	13 Feb 2023
DOIs	https://doi.org/10.1111/cdev.13914
Publication status	Published - 1 Jul 2023

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Child Development - 2023 - Abbondanza - Language and reading impairments are associated with increased prevalence of
© 2023 The Authors.
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Abbondanza, F., Dale, P. S., Wang, C. A., Hayiou-Thomas, E., Toseeb, U., Koomar, T. S., Wigg, K. G., Feng, Y., Price, K. M., Kerr, E., Guger, S. L., Lovett, M. W., Strug, L. J., van Bergen, E., Dolan, C. V., Tomblin, J. B., Moll, K., Schulte-Körne, G., Neuhoff, N., ... Paracchini, S. (2023). Language and reading impairments are associated with increased prevalence of non-right-handedness. Child Development, 94(4), 970-984. https://doi.org/10.1111/cdev.13914

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title = "Language and reading impairments are associated with increased prevalence of non-right-handedness",

abstract = "Worldwide, the majority of people prefer using the right hand for most motor tasks. Because of the link between handedness and language hemispheric dominance, handedness has been studied for association with language-related disorders. No clear pattern has emerged from these studies, and inconsistencies have been attributed to small sample sizes, publication bias, and heterogeneous criteria for the definition of handedness and disorders.Here, we assessed the frequency of non-right handedness (NRH) in 10 distinct cohorts not analysed before in this context. We identified N = 2,528 cases with reading and/or language impairment and N = 3,050 unique controls on the basis of a priori defined criteria. Overall, NRH was more frequent and more variable in the cases (8-24%) than in the controls (8-16%). Meta-analysis in the eight cohorts that met the inclusion criteria showed an increase of NRH in individuals with language/reading impairment compared to controls (OR = 1.21, CI = 1.03 - 1.44, p = 0.025). No moderator effects were detected for type of cohort (epidemiological versus clinical) and type of impairment (language versus reading). Our results support an association between NRH and reading and language impairments which could result from shared biological pathways underlying brain lateralization, handedness, and cognitive functions",

author = "Filippo Abbondanza and Dale, {Philip S.} and Wang, {Carol A.} and Emma Hayiou-Thomas and Umar Toseeb and Koomar, {Tanner S} and Wigg, {Karen G} and Yu Feng and Price, {Kaitlyn M} and Elizabeth Kerr and Guger, {Sharon L} and Lovett, {Maureen W} and Strug, {Lisa J} and {van Bergen}, Elsje and Dolan, {Conor V.} and Tomblin, {J Bruce} and Kristina Moll and Gerd Schulte-K{\"o}rne and Nina Neuhoff and Andreas Warnke and Fisher, {Simon E.} and Barr, {Cathy L} and Michaelson, {Jacob J} and Boomsma, {Dorret I.} and Snowling, {Margaret Jean} and Charles Hulme and Whitehouse, {Andrew J.O.} and Pennell, {Craig E} and Newbury, {Dianne F} and John Stein and Talcott, {Joel B.} and Bishop, {Dorothy V. M.} and Silvia Paracchini",

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year = "2023",

month = jul,

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doi = "10.1111/cdev.13914",

language = "English",

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journal = "Child Development",

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Abbondanza, F, Dale, PS, Wang, CA, Hayiou-Thomas, E , Toseeb, U, Koomar, TS, Wigg, KG, Feng, Y, Price, KM, Kerr, E, Guger, SL, Lovett, MW, Strug, LJ, van Bergen, E, Dolan, CV, Tomblin, JB, Moll, K, Schulte-Körne, G, Neuhoff, N, Warnke, A, Fisher, SE, Barr, CL, Michaelson, JJ, Boomsma, DI, Snowling, MJ, Hulme, C, Whitehouse, AJO, Pennell, CE, Newbury, DF, Stein, J, Talcott, JB, Bishop, DVM & Paracchini, S 2023, 'Language and reading impairments are associated with increased prevalence of non-right-handedness', Child Development, vol. 94, no. 4, pp. 970-984. https://doi.org/10.1111/cdev.13914

TY - JOUR

T1 - Language and reading impairments are associated with increased prevalence of non-right-handedness

AU - Abbondanza, Filippo

AU - Dale, Philip S.

AU - Wang, Carol A.

AU - Hayiou-Thomas, Emma

AU - Toseeb, Umar

AU - Koomar, Tanner S

AU - Wigg, Karen G

AU - Feng, Yu

AU - Price, Kaitlyn M

AU - Kerr, Elizabeth

AU - Guger, Sharon L

AU - Lovett, Maureen W

AU - Strug, Lisa J

AU - van Bergen, Elsje

AU - Dolan, Conor V.

AU - Tomblin, J Bruce

AU - Moll, Kristina

AU - Schulte-Körne, Gerd

AU - Neuhoff, Nina

AU - Warnke, Andreas

AU - Fisher, Simon E.

AU - Barr, Cathy L

AU - Michaelson, Jacob J

AU - Boomsma, Dorret I.

AU - Snowling, Margaret Jean

AU - Hulme, Charles

AU - Whitehouse, Andrew J.O.

AU - Pennell, Craig E

AU - Newbury, Dianne F

AU - Stein, John

AU - Talcott, Joel B.

AU - Bishop, Dorothy V. M.

AU - Paracchini, Silvia

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Worldwide, the majority of people prefer using the right hand for most motor tasks. Because of the link between handedness and language hemispheric dominance, handedness has been studied for association with language-related disorders. No clear pattern has emerged from these studies, and inconsistencies have been attributed to small sample sizes, publication bias, and heterogeneous criteria for the definition of handedness and disorders.Here, we assessed the frequency of non-right handedness (NRH) in 10 distinct cohorts not analysed before in this context. We identified N = 2,528 cases with reading and/or language impairment and N = 3,050 unique controls on the basis of a priori defined criteria. Overall, NRH was more frequent and more variable in the cases (8-24%) than in the controls (8-16%). Meta-analysis in the eight cohorts that met the inclusion criteria showed an increase of NRH in individuals with language/reading impairment compared to controls (OR = 1.21, CI = 1.03 - 1.44, p = 0.025). No moderator effects were detected for type of cohort (epidemiological versus clinical) and type of impairment (language versus reading). Our results support an association between NRH and reading and language impairments which could result from shared biological pathways underlying brain lateralization, handedness, and cognitive functions

AB - Worldwide, the majority of people prefer using the right hand for most motor tasks. Because of the link between handedness and language hemispheric dominance, handedness has been studied for association with language-related disorders. No clear pattern has emerged from these studies, and inconsistencies have been attributed to small sample sizes, publication bias, and heterogeneous criteria for the definition of handedness and disorders.Here, we assessed the frequency of non-right handedness (NRH) in 10 distinct cohorts not analysed before in this context. We identified N = 2,528 cases with reading and/or language impairment and N = 3,050 unique controls on the basis of a priori defined criteria. Overall, NRH was more frequent and more variable in the cases (8-24%) than in the controls (8-16%). Meta-analysis in the eight cohorts that met the inclusion criteria showed an increase of NRH in individuals with language/reading impairment compared to controls (OR = 1.21, CI = 1.03 - 1.44, p = 0.025). No moderator effects were detected for type of cohort (epidemiological versus clinical) and type of impairment (language versus reading). Our results support an association between NRH and reading and language impairments which could result from shared biological pathways underlying brain lateralization, handedness, and cognitive functions

U2 - 10.1111/cdev.13914

DO - 10.1111/cdev.13914

M3 - Article

SN - 0009-3920

VL - 94

SP - 970

EP - 984

JO - Child Development

JF - Child Development

IS - 4

ER -