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Lateral Transfer of Genes for Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) Degradation

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JournalApplied and Environmental Microbiology
DatePublished - 15 May 2009
Issue number10
Volume75
Number of pages5
Pages (from-to)3258-3262
Original languageEnglish

Abstract

Recent studies demonstrated that degradation of the military explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by species of Rhodococcus, Gordonia, and Williamsia is mediated by a novel cytochrome P450 with a fused flavodoxin reductase domain (XplA) in conjunction with a flavodoxin reductase (XplB). Pulse field gel analysis was used to localize xplA to extrachromosomal elements in a Rhodococcus sp. and distantly related Microbacterium sp. strain MA1. Comparison of Rhodococcus rhodochrous 11Y and Microbacterium plasmid sequences in the vicinity of xplB and xplA showed near identity (6,710 of 6,721 bp). Sequencing of the associated 52.2-kb region of the Microbacterium plasmid pMA1 revealed flanking insertion sequence elements and additional genes implicated in RDX uptake and degradation.

    Research areas

  • STRAIN DN22, SEQUENCE DATA, RHODOCOCCUS, BIODEGRADATION, BACTERIA, SYSTEM, CYTOCHROME-P-450, ENVIRONMENT, EXPLOSIVES, ADAPTATION

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