Leaky Endosomes Push Tau Over the Seed Limit

Christopher Ugbode; Laura Fort Aznar; Sean Sweeney

doi:10.1074/jbc.H119.011687

Leaky Endosomes Push Tau Over the Seed Limit

Christopher Ugbode, Laura Fort Aznar, Sean Sweeney

Biology

Research output: Contribution to journal › Review article

Abstract

The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al. now combine a cell-based model of tau aggregation with a CRISPR interference (CRISPRi) genetic screen to identify components of the endosomal sorting complex required for transport (ESCRT) machinery as mediators of intracellular propagation of tau aggregates. These findings reveal a role for endolysosomal integrity in blocking tau propagation.

Original language	English
Pages (from-to)	18967-18968
Number of pages	1
Journal	Journal of Biological Chemistry
Volume	294
Issue number	50
DOIs	https://doi.org/10.1074/jbc.H119.011687
Publication status	Published - 13 Dec 2019

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10.1074/jbc.H119.011687

Cite this

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title = "Leaky Endosomes Push Tau Over the Seed Limit",

abstract = "The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al. now combine a cell-based model of tau aggregation with a CRISPR interference (CRISPRi) genetic screen to identify components of the endosomal sorting complex required for transport (ESCRT) machinery as mediators of intracellular propagation of tau aggregates. These findings reveal a role for endolysosomal integrity in blocking tau propagation.",

author = "Christopher Ugbode and {Fort Aznar}, Laura and Sean Sweeney",

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AU - Fort Aznar, Laura

AU - Sweeney, Sean

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N2 - The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al. now combine a cell-based model of tau aggregation with a CRISPR interference (CRISPRi) genetic screen to identify components of the endosomal sorting complex required for transport (ESCRT) machinery as mediators of intracellular propagation of tau aggregates. These findings reveal a role for endolysosomal integrity in blocking tau propagation.

AB - The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al. now combine a cell-based model of tau aggregation with a CRISPR interference (CRISPRi) genetic screen to identify components of the endosomal sorting complex required for transport (ESCRT) machinery as mediators of intracellular propagation of tau aggregates. These findings reveal a role for endolysosomal integrity in blocking tau propagation.

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DO - 10.1074/jbc.H119.011687

M3 - Review article

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JF - The Journal of biological chemistry

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