Leaky Endosomes Push Tau Over the Seed Limit

Christopher Ugbode, Laura Fort Aznar, Sean Sweeney

Research output: Contribution to journalReview article


The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al. now combine a cell-based model of tau aggregation with a CRISPR interference (CRISPRi) genetic screen to identify components of the endosomal sorting complex required for transport (ESCRT) machinery as mediators of intracellular propagation of tau aggregates. These findings reveal a role for endolysosomal integrity in blocking tau propagation.
Original languageEnglish
Pages (from-to)18967-18968
Number of pages1
JournalJournal of Biological Chemistry
Issue number50
Publication statusPublished - 13 Dec 2019

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