By the same authors

From the same journal

From the same journal

Leaky Endosomes Push Tau Over the Seed Limit

Research output: Contribution to journalReview article

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalJournal of Biological Chemistry
DatePublished - 13 Dec 2019
Issue number50
Volume294
Number of pages1
Pages (from-to)18967-18968
Original languageEnglish

Abstract

The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al. now combine a cell-based model of tau aggregation with a CRISPR interference (CRISPRi) genetic screen to identify components of the endosomal sorting complex required for transport (ESCRT) machinery as mediators of intracellular propagation of tau aggregates. These findings reveal a role for endolysosomal integrity in blocking tau propagation.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations