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Leaky Endosomes Push Tau Over the Seed Limit
Research output: Contribution to journal › Review article
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Publication details
| Journal | Journal of Biological Chemistry |
|---|---|
| Date | Published - 13 Dec 2019 |
| Issue number | 50 |
| Volume | 294 |
| Number of pages | 1 |
| Pages (from-to) | 18967-18968 |
| Original language | English |
Abstract
The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central mechanism behind progression of various neurodegenerative diseases. The steps by which tau aggregates and propagates is currently unclear. Chen et al. now combine a cell-based model of tau aggregation with a CRISPR interference (CRISPRi) genetic screen to identify components of the endosomal sorting complex required for transport (ESCRT) machinery as mediators of intracellular propagation of tau aggregates. These findings reveal a role for endolysosomal integrity in blocking tau propagation.
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