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Leishmaniasis immunopathology-impact on design and use of vaccines, diagnostics and drugs
Research output: Contribution to journal › Review article › peer-review
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Publication details
| Journal | Seminars in immunopathology |
|---|---|
| Date | Accepted/In press - 3 Feb 2020 |
| Date | E-pub ahead of print (current) - 9 Mar 2020 |
| Number of pages | 18 |
| Pages (from-to) | 1-18 |
| Early online date | 9/03/20 |
| Original language | English |
Abstract
Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis (VL) and cutaneous or tegumentary leishmaniasis (CL), as well as several other cutaneous manifestations in a minority of cases. In the mammalian host Leishmania parasites infect different populations of macrophages where they multiply and survive in the phagolysosomal compartment. The progression of both VL and CL depends on the maintenance of a parasite-specific immunosuppressive state based around this host macrophage infection. The complexity and variation of immune responses and immunopathology in humans and the different host interactions of the different Leishmania species has an impact upon the effectiveness of vaccines, diagnostics and drugs.
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© 2020 Springer Nature Switzerland AG. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
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