Long-lived States to Sustain SABRE Hyperpolarised Magnetisation

Soumya Singha Roy; Peter John Rayner; Philip Norcott; Gary George Reginald Green; Simon Duckett

doi:10.1039/C6CP02844F

Long-lived States to Sustain SABRE Hyperpolarised Magnetisation

Soumya Singha Roy, Peter John Rayner, Philip Norcott, Gary George Reginald Green, Simon Duckett

Research output: Contribution to journal › Article › peer-review

Abstract

The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4 % net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future

Original language	English
Pages (from-to)	24905-24911
Number of pages	7
Journal	Physical chemistry chemical physics : PCCP
Volume	18
Issue number	36
Early online date	15 Aug 2016
DOIs	https://doi.org/10.1039/C6CP02844F
Publication status	Published - 28 Sep 2016

Bibliographical note

© The Royal Society of Chemistry, 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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10.1039/C6CP02844FLicence: CC BY

PCCP_Paper_Revised_final
© The Royal Society of Chemistry, 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. Embargo period : 12 months
Accepted author manuscript, 544 KBLicence: CC BY

Hyperpolarisation using SABRE as a new tool for imaging
Duckett, S. B. & Green, G. G. R.
1/10/12 → 31/03/19
Project: Research project (funded) › Research

Cite this

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abstract = "The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4 % net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future",

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AU - Norcott, Philip

AU - Green, Gary George Reginald

AU - Duckett, Simon

N1 - © The Royal Society of Chemistry, 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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N2 - The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4 % net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future

AB - The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4 % net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future

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DO - 10.1039/C6CP02844F

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JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

IS - 36

ER -

Long-lived States to Sustain SABRE Hyperpolarised Magnetisation

Abstract

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Hyperpolarisation using SABRE as a new tool for imaging

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